Interleukin-7 Is Associated with Clinical and Pathological Activities in Immunoglobulin A Nephropathy and Protects the Renal Proximal Tubule Epithelium from Cellular Fibrosis

Objective Diagnosis of immunoglobulin A nephropathy (IgAN) requires the evaluation of renal biopsy specimens. However, renal biopsy is an invasive procedure and is not frequently performed for various reasons. Thus, recognized noninvasive biomarkers for predicting IgAN progression are urgently neede...

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Bibliographic Details
Published in:Current medical science 2021-10, Vol.41 (5), p.880-887
Main Authors: Deng, Yuan-jun, Lin, Xue-ping, Li, Xiao-qing, Lu, Ping-fan, Cai, Yang, Liu, Le-le, Pei, Guang-chang, Han, Min
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Autophagy
Biomarkers - metabolism
Case-Control Studies
Cells, Cultured
Disease Models, Animal
Disease Progression
Down-Regulation
Female
Glomerulonephritis, IGA - immunology
Glomerulonephritis, IGA - metabolism
Glomerulonephritis, IGA - pathology
Humans
Interleukin-7 - blood
Interleukin-7 - metabolism
Kidney Tubules, Proximal - cytology
Kidney Tubules, Proximal - metabolism
Kidney Tubules, Proximal - pathology
Male
Medicine
Medicine & Public Health
Mice
Middle Aged
Rats
Signal Transduction
TOR Serine-Threonine Kinases - metabolism
Transforming Growth Factor beta1 - metabolism
Young Adult
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Summary:Objective Diagnosis of immunoglobulin A nephropathy (IgAN) requires the evaluation of renal biopsy specimens. However, renal biopsy is an invasive procedure and is not frequently performed for various reasons. Thus, recognized noninvasive biomarkers for predicting IgAN progression are urgently needed. Methods In the present study, we included 86 IgAN patients with renal biopsy from June 2015 to May 2016 and had their plasma interleukin-7 (IL-7) level measured with ELISA. The association between the plasma IL-7 level and clinico-pathological characteristics was analyzed. Immunohistochemical staining was used to assay the in situ expression of IL-7 in vivo . Western blotting was performed to examine the production of extracellular matrix, p-mTOR and the markers of autophagy under the treatment of IL-7 after TGF-β1 stimulation in renal tubular epithelial cells. Results IL-7 was significantly decreased in patients with IgAN compared to healthy subjects (2.3077 vs. 8.6294 pg/mL, P
ISSN:2096-5230
2523-899X
DOI:10.1007/s11596-021-2409-z