Novel nanoformulated diethyldithiocarbamate complexes with biosynthesized or green chemosynthesized copper oxide nanoparticles: An in vitro comparative anticancer study

• Published in: International journal of pharmaceutics 2021-11, Vol.609, p.121149-121149, Article 121149
• Main Authors: Abu‑Serie, Marwa M., Eltarahony, Marwa
• Format: Article
• Language: English
• Subjects: Anti-cancer cell migration; Apoptosis-dependent anticancer efficacy; Biosynthesized cupric oxide nanoparticles; Cellular redox status; Diethyldithiocarbamate nanocomplexes; Green chemosynthesized cuprous oxide nanoparticles
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2021.121149

[Display omitted] •Novel nanoformulation of diethyldithiocarbamate by cupper oxide nanoparticles (NPs).•Bacterially (Bio) and green chemically (Chemo) synthesized cupper oxide NPs were used.•Cellular uptake and prooxidant activity of Chemo nanocomplex (CD) was better.•Thus Chemo CD NPs had stronger apoptotic anticancer effect than Bio CD NPs (in vitro).•Halting lung, colon, liver and prostate cancer migration was higher in Chemo CD NPs. Developing more soluble and stable nanoformulation for the potent anticancer complex of copper diethyldithiocarbamate (CD) is extremely desired. Herein, for the first time, CD nanoparticles (NPs) were formulated by chelating diethyldithiocarbamate to bacterially and green chemically prepared copper oxide NPs (Bio CO NPs and Chemo CO NPs, respectively). Chemo CO NPs were produced in simpler and less time-consuming manner with higher NPs homogeneity. These CO NPs were identified, by X-ray diffractometer, as CuO and Cu2O, respectively. The nanoformulated CD complexes (Bio CD NPs and Chemo CD NPs) which have nanosizes (215.7 nm and 148.1 nm, respectively) with negative zeta potentials (∼−20 mv), exhibited not only high serum stability and solubility but also a potent anticancer effect. More importantly, Chemo CD NPs outperformed Bio CD NPs in the terms of synergistic anticancer index, apoptosis induction (>81% and