Determinants of oxygen uptake and prognostic factors in cardiopulmonary exercise test in patients with Fontan surgery

• Published in: Cardiology in the young 2022-08, Vol.32 (8), p.1285-1288
• Main Authors: Martin Talavera, Maria, Manso, Begoña, Cejudo Ramos, Pilar, Rodriguez Puras, Maria Jose, Wals Rodriguez, Amadeo J, Garcia de Vinuesa, Pastora Gallego
• Format: Article
• Language: English
• Subjects: Age; Anaerobic threshold; Body mass; Body mass index; Body size; Carbon dioxide; Clinical deterioration; Correlation coefficient; Correlation coefficients; Evolution; Heart rate; Independent variables; Maximum oxygen consumption; Multivariate analysis; Original Article; Oxygen; Oxygen consumption; Oxygen uptake; Parameters; Patients; Physiology; Psychosocial/Exercise/Obesity/Quality of Life; Pulmonary arteries; Quality of life; Regression analysis; Regression models; Sex; Surgery; Ventilation
• ISSN: 1047-9511; 1467-1107
• DOI: 10.1017/S1047951121004054

Introduction:Cardiopulmonary exercise test (CPET) allows quantification of functional capacity of patients with Fontan. The objective of this study was to determine the role of CPET parameters in predicting a higher maximum oxygen consumption (VO2 max) and to analyse the role of CPET parameters in predicting an unfavourable outcome.Methods:A retrospective, cross-sectional, descriptive study was carried out on 57 patients with Fontan, who had undergone incremental CPET with cycloergometer between 2010 and 2020. Determinants of VO2 max and determinants of clinical deterioration were analysed.Results:In the univariate analysis, the variables significantly related to VO2 max were: age, sex, body mass index (BMI), years of Fontan evolution, intracardiac Fontan, oxygen consumption at anaerobic threshold (VO2AT), CO2 equivalents at anaerobic threshold (VE/VCO2) and chronotropic insufficiency. The multiple linear regression model that best fitted the relationship between VO2 max and independent variables (correlation coefficient 0.73) included sex (correlation index 3.35; p = 0.02), BMI (−0.27; p = 0.02), chronotropic failure (−2.79; p = 0.01) and VO2AT (0.92; p < 0.0001). In the univariate analysis of the prognostic CPET variables related to an unfavourable clinical situation, significance was only obtained with chronotropic insufficiency (p = 0.003). In multivariate analysis, chronotropic insufficiency maintains its association [p= 0.017, OR = 4.65 (1.3–16.5)].Conclusions:In conclusion, together with the anthropometric parameters universally related to VO2 max, chronotropic insufficiency and VO2AT are the main determinants of functional capacity in patients with Fontan. Moreover, chronotropic insufficiency is closely related to unfavourable clinical evolution. Our data would support the intensive treatment of chronotropic insufficiency in order to improve the quality of life and the clinical situation of patients with Fontan.