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People Who Inject Drugs and have tuberculosis: Opioid Substitution Therapy improves treatment outcomes in Ukraine
Opioid substitution therapy (OST) is one of the pillars of harm reduction strategies for People Who Inject Drugs (PWID). It should be an integral part of tuberculosis (TB) care to increase the uptake, compliance and effectiveness of treatment and also curtail risk behaviors. We aimed to compare TB t...
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| Published in: | Journal of infection in developing countries 2021-09, Vol.15 (9.1), p.51S-57S |
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| Main Authors: | , , , , , , |
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| Language: | English |
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| container_end_page | 57S |
| container_issue | 9.1 |
| container_start_page | 51S |
| container_title | Journal of infection in developing countries |
| container_volume | 15 |
| creator | Fomenko, Tetiana Meteliuk, Anna Korinchuk, Larysa Denisiuk, Olga Aslanyan, Garry Islam, Zahedul Zachariah, Rony |
| description | Opioid substitution therapy (OST) is one of the pillars of harm reduction strategies for People Who Inject Drugs (PWID). It should be an integral part of tuberculosis (TB) care to increase the uptake, compliance and effectiveness of treatment and also curtail risk behaviors. We aimed to compare TB treatment outcomes in relation to OST among PWID in six regions of Ukraine.
A retrospective cohort study using routine programmatic data from centers offering integrated TB and OST (December 2016 - May 2020). OST involved use of methadone or buprenorphine. TB treatment outcomes were standardized.
Of 228 PWID (85% male) diagnosed with TB, 104 (46%) had drug-sensitive and 124 (64%) drug-resistant TB. The majority had pulmonary TB (95%), 64 (28%) were HCV-positive and 179 (78%) were HIV-positive, 91% of the latter were also on antiretroviral therapy. There were 114 (50%) PWID with TB on OST. For drug-sensitive TB (n=104), treatment success was significantly higher (61%) in those on adjunctive OST than those not on OST (42%, P |
| doi_str_mv | 10.3855/jidc.13759 |
| format | article |
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A retrospective cohort study using routine programmatic data from centers offering integrated TB and OST (December 2016 - May 2020). OST involved use of methadone or buprenorphine. TB treatment outcomes were standardized.
Of 228 PWID (85% male) diagnosed with TB, 104 (46%) had drug-sensitive and 124 (64%) drug-resistant TB. The majority had pulmonary TB (95%), 64 (28%) were HCV-positive and 179 (78%) were HIV-positive, 91% of the latter were also on antiretroviral therapy. There were 114 (50%) PWID with TB on OST. For drug-sensitive TB (n=104), treatment success was significantly higher (61%) in those on adjunctive OST than those not on OST (42%, P<0.001). Similarly, for drug-resistant TB (n=124) treatment success was also significantly higher when individuals were on OST (43%) compared to when not on OST (26%, P<0.001).
This operational research study shows that OST is associated with significantly improved treatment success in PWID and can contribute to achieving Universal Health Coverage and the WHO Flagship Initiative "Find.Treat.All. #End TB". We advocate for the scale-up of this intervention in Ukraine.</description><identifier>ISSN: 1972-2680</identifier><identifier>ISSN: 2036-6590</identifier><identifier>EISSN: 1972-2680</identifier><identifier>DOI: 10.3855/jidc.13759</identifier><identifier>PMID: 34609960</identifier><language>eng</language><publisher>Italy: Journal of Infection in Developing Countries</publisher><subject>Adult ; Analgesics, Opioid ; Clinical outcomes ; Drug resistance ; Female ; Humans ; Male ; Middle Aged ; Narcotic Antagonists - therapeutic use ; Narcotics ; Opiate Substitution Treatment - methods ; Retrospective Studies ; Substance Abuse, Intravenous - drug therapy ; Substance Abuse, Intravenous - epidemiology ; Success ; Treatment Outcome ; Tuberculosis ; Tuberculosis, Pulmonary - epidemiology ; Ukraine - epidemiology</subject><ispartof>Journal of infection in developing countries, 2021-09, Vol.15 (9.1), p.51S-57S</ispartof><rights>Copyright (c) 2021 Tetiana Fomenko, Anna Meteliuk, Larysa Korinchuk, Olga Denisiuk, Garry Aslanyan, Zahedul Islam, Rony Zachariah.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3131776687?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34609960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fomenko, Tetiana</creatorcontrib><creatorcontrib>Meteliuk, Anna</creatorcontrib><creatorcontrib>Korinchuk, Larysa</creatorcontrib><creatorcontrib>Denisiuk, Olga</creatorcontrib><creatorcontrib>Aslanyan, Garry</creatorcontrib><creatorcontrib>Islam, Zahedul</creatorcontrib><creatorcontrib>Zachariah, Rony</creatorcontrib><title>People Who Inject Drugs and have tuberculosis: Opioid Substitution Therapy improves treatment outcomes in Ukraine</title><title>Journal of infection in developing countries</title><addtitle>J Infect Dev Ctries</addtitle><description>Opioid substitution therapy (OST) is one of the pillars of harm reduction strategies for People Who Inject Drugs (PWID). It should be an integral part of tuberculosis (TB) care to increase the uptake, compliance and effectiveness of treatment and also curtail risk behaviors. We aimed to compare TB treatment outcomes in relation to OST among PWID in six regions of Ukraine.
A retrospective cohort study using routine programmatic data from centers offering integrated TB and OST (December 2016 - May 2020). OST involved use of methadone or buprenorphine. TB treatment outcomes were standardized.
Of 228 PWID (85% male) diagnosed with TB, 104 (46%) had drug-sensitive and 124 (64%) drug-resistant TB. The majority had pulmonary TB (95%), 64 (28%) were HCV-positive and 179 (78%) were HIV-positive, 91% of the latter were also on antiretroviral therapy. There were 114 (50%) PWID with TB on OST. For drug-sensitive TB (n=104), treatment success was significantly higher (61%) in those on adjunctive OST than those not on OST (42%, P<0.001). Similarly, for drug-resistant TB (n=124) treatment success was also significantly higher when individuals were on OST (43%) compared to when not on OST (26%, P<0.001).
This operational research study shows that OST is associated with significantly improved treatment success in PWID and can contribute to achieving Universal Health Coverage and the WHO Flagship Initiative "Find.Treat.All. #End TB". We advocate for the scale-up of this intervention in Ukraine.</description><subject>Adult</subject><subject>Analgesics, Opioid</subject><subject>Clinical outcomes</subject><subject>Drug resistance</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Narcotic Antagonists - therapeutic use</subject><subject>Narcotics</subject><subject>Opiate Substitution Treatment - methods</subject><subject>Retrospective Studies</subject><subject>Substance Abuse, Intravenous - drug therapy</subject><subject>Substance Abuse, Intravenous - epidemiology</subject><subject>Success</subject><subject>Treatment Outcome</subject><subject>Tuberculosis</subject><subject>Tuberculosis, Pulmonary - epidemiology</subject><subject>Ukraine - epidemiology</subject><issn>1972-2680</issn><issn>2036-6590</issn><issn>1972-2680</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkdtKxDAQhoMoHlZvfAAJeCNCNWnapPFOPIOwgoqXJW2nbmrbdHMQ9u3tuquIVzMMHz8_8yF0SMkZy9L0vNFVeUaZSOUG2qVSxFHMM7L5Z99Be841hKSSpXQb7bCEEyk52UXzJzBDC_htZvBD30Dp8bUN7w6rvsIz9QnYhwJsGVrjtLvA00EbXeHnUDivffDa9PhlBlYNC6y7wZpPcNhbUL6D3mMTfGm68aR7_Pphle5hH23VqnVwsJ4T9Hp783J1Hz1O7x6uLh-jMhaJjxhIokhCIBNUJTVVjFOecgYgMppUpEjrWBBVlTEUmRIsoTVwRitRM0l4wdgEnaxyx1LzAM7nnXYltK3qwQSXx6mQfIwQckSP_6GNCbYf2-WMMioE55kYqdMVVVrjnIU6H6zulF3klORLEflSRP4tYoSP1pGh6KD6RX8-z74AcCOEgQ</recordid><startdate>20210929</startdate><enddate>20210929</enddate><creator>Fomenko, Tetiana</creator><creator>Meteliuk, Anna</creator><creator>Korinchuk, Larysa</creator><creator>Denisiuk, Olga</creator><creator>Aslanyan, Garry</creator><creator>Islam, Zahedul</creator><creator>Zachariah, Rony</creator><general>Journal of Infection in Developing Countries</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8C1</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20210929</creationdate><title>People Who Inject Drugs and have tuberculosis: Opioid Substitution Therapy improves treatment outcomes in Ukraine</title><author>Fomenko, Tetiana ; Meteliuk, Anna ; Korinchuk, Larysa ; Denisiuk, Olga ; Aslanyan, Garry ; Islam, Zahedul ; Zachariah, Rony</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-3e90a040e871a4f1a3616563ee7814d0b5f270adc2eb8a7341fe631d7f3906b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Analgesics, Opioid</topic><topic>Clinical outcomes</topic><topic>Drug resistance</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Narcotic Antagonists - therapeutic use</topic><topic>Narcotics</topic><topic>Opiate Substitution Treatment - methods</topic><topic>Retrospective Studies</topic><topic>Substance Abuse, Intravenous - drug therapy</topic><topic>Substance Abuse, Intravenous - epidemiology</topic><topic>Success</topic><topic>Treatment Outcome</topic><topic>Tuberculosis</topic><topic>Tuberculosis, Pulmonary - epidemiology</topic><topic>Ukraine - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fomenko, Tetiana</creatorcontrib><creatorcontrib>Meteliuk, Anna</creatorcontrib><creatorcontrib>Korinchuk, Larysa</creatorcontrib><creatorcontrib>Denisiuk, Olga</creatorcontrib><creatorcontrib>Aslanyan, Garry</creatorcontrib><creatorcontrib>Islam, Zahedul</creatorcontrib><creatorcontrib>Zachariah, Rony</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Public Health Database</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of infection in developing countries</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fomenko, Tetiana</au><au>Meteliuk, Anna</au><au>Korinchuk, Larysa</au><au>Denisiuk, Olga</au><au>Aslanyan, Garry</au><au>Islam, Zahedul</au><au>Zachariah, Rony</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>People Who Inject Drugs and have tuberculosis: Opioid Substitution Therapy improves treatment outcomes in Ukraine</atitle><jtitle>Journal of infection in developing countries</jtitle><addtitle>J Infect Dev Ctries</addtitle><date>2021-09-29</date><risdate>2021</risdate><volume>15</volume><issue>9.1</issue><spage>51S</spage><epage>57S</epage><pages>51S-57S</pages><issn>1972-2680</issn><issn>2036-6590</issn><eissn>1972-2680</eissn><abstract>Opioid substitution therapy (OST) is one of the pillars of harm reduction strategies for People Who Inject Drugs (PWID). It should be an integral part of tuberculosis (TB) care to increase the uptake, compliance and effectiveness of treatment and also curtail risk behaviors. We aimed to compare TB treatment outcomes in relation to OST among PWID in six regions of Ukraine.
A retrospective cohort study using routine programmatic data from centers offering integrated TB and OST (December 2016 - May 2020). OST involved use of methadone or buprenorphine. TB treatment outcomes were standardized.
Of 228 PWID (85% male) diagnosed with TB, 104 (46%) had drug-sensitive and 124 (64%) drug-resistant TB. The majority had pulmonary TB (95%), 64 (28%) were HCV-positive and 179 (78%) were HIV-positive, 91% of the latter were also on antiretroviral therapy. There were 114 (50%) PWID with TB on OST. For drug-sensitive TB (n=104), treatment success was significantly higher (61%) in those on adjunctive OST than those not on OST (42%, P<0.001). Similarly, for drug-resistant TB (n=124) treatment success was also significantly higher when individuals were on OST (43%) compared to when not on OST (26%, P<0.001).
This operational research study shows that OST is associated with significantly improved treatment success in PWID and can contribute to achieving Universal Health Coverage and the WHO Flagship Initiative "Find.Treat.All. #End TB". We advocate for the scale-up of this intervention in Ukraine.</abstract><cop>Italy</cop><pub>Journal of Infection in Developing Countries</pub><pmid>34609960</pmid><doi>10.3855/jidc.13759</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1972-2680 |
| ispartof | Journal of infection in developing countries, 2021-09, Vol.15 (9.1), p.51S-57S |
| issn | 1972-2680 2036-6590 1972-2680 |
| language | eng |
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| subjects | Adult Analgesics, Opioid Clinical outcomes Drug resistance Female Humans Male Middle Aged Narcotic Antagonists - therapeutic use Narcotics Opiate Substitution Treatment - methods Retrospective Studies Substance Abuse, Intravenous - drug therapy Substance Abuse, Intravenous - epidemiology Success Treatment Outcome Tuberculosis Tuberculosis, Pulmonary - epidemiology Ukraine - epidemiology |
| title | People Who Inject Drugs and have tuberculosis: Opioid Substitution Therapy improves treatment outcomes in Ukraine |
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