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The therapeutic role of lasers in primary localized cutaneous amyloidosis: a systematic review

With the investigation of the efficacy of laser therapy in primary localized amyloidosis(PLCA) only recently starting to materialize, we aimed to review the currently available studies of laser therapy in the management of the disease. We searched PubMed, Scopus, Embase, Web of Science, Cochrane, an...

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Published in:Lasers in medical science 2022-03, Vol.37 (2), p.799-813
Main Authors: Ahramiyanpour, Najmeh, Akbari, Zahra, Sarasyabi, Mohammad Sharifi, Aflatoonian, Mahin, Saki, Nasrin, Shafie’ei, Mohammad
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creator Ahramiyanpour, Najmeh
Akbari, Zahra
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Shafie’ei, Mohammad
description With the investigation of the efficacy of laser therapy in primary localized amyloidosis(PLCA) only recently starting to materialize, we aimed to review the currently available studies of laser therapy in the management of the disease. We searched PubMed, Scopus, Embase, Web of Science, Cochrane, and ProQuest online databases with a specified search strategy, assessed the quality of each study, and then extracted the eligible data. Five RCTs(randomized controlled trials), one non-randomized controlled trial, three case series, and nine case reports(18 in total) were included. Overall, carbon dioxide (CO2), neodymium-doped:yttrium aluminum garnet (Nd:YAG), pulsed dye (PDL), Er (Erbium):YAG, and yttrium/erbium fiber were the studied lasers. One hundred fifty-five cases in total underwent laser therapy, with CO2 being the most frequent laser. Almost all studies demonstrated significantly desirable outcomes, while only mild and transient side effects were noted. Even though the studies’ results were significant, we noticed that implementing a consistent methodology and a standardized objective assessment method was missing. Therefore, we recommend that future studies be conducted with less heterogeneous data for a more definite conclusion.
doi_str_mv 10.1007/s10103-021-03429-4
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subjects Aluminum
Amyloidosis
Amyloidosis, Familial
Carbon dioxide
Case reports
Dentistry
Erbium
Humans
Laser Therapy - methods
Lasers
Lasers, Solid-State - therapeutic use
Medicine
Medicine & Public Health
Neodymium
Optical Devices
Optics
Photonics
Quality assessment
Quantum Optics
Randomized Controlled Trials as Topic
Review Article
Side effects
Skin Diseases, Genetic
Therapy
Yttrium
Yttrium-aluminum garnet
title The therapeutic role of lasers in primary localized cutaneous amyloidosis: a systematic review
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