The use of mice in diabetes research: The impact of physiological characteristics, choice of model and husbandry practices

Diabetes mellitus is characterised by hyperglycaemia, which results from an absolute or relative lack of insulin. Chronic and acute hyperglycaemia are associated with a range of health complications and an overall increased risk of mortality. Mouse models are vital in understanding the pathogenesis...

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Bibliographic Details
Published in:Diabetic medicine 2021-12, Vol.38 (12), p.e14711-n/a
Main Authors: Daniels Gatward, Lydia F., Kennard, Matilda R., Smith, Lorna I. F., King, Aileen J. F.
Format: Article
Language:English
Subjects:
Animal husbandry
Animal models
Animals
Biomedical Research - methods
breeding
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental - genetics
Diabetes Mellitus, Experimental - therapy
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - therapy
Disease Management
husbandry
Hyperglycemia
Insulin
Insulin Resistance - physiology
Medical research
Mice
mouse models
physiological characteristics
Physiology
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Summary:Diabetes mellitus is characterised by hyperglycaemia, which results from an absolute or relative lack of insulin. Chronic and acute hyperglycaemia are associated with a range of health complications and an overall increased risk of mortality. Mouse models are vital in understanding the pathogenesis of this disease and its complications, as well as for developing new diabetes therapeutics. However, for experimental questions to be suitably tested, it is critical that factors inherent to the animal model are considered, as these can have profound impacts on experimental outcome, data reproducibility and robustness. In this review, we discuss key considerations relating to model choice, physiological characteristics (such as age, sex and genetic background) and husbandry practices and explore the impact of these on common experimental readouts used in preclinical diabetes research.
ISSN:0742-3071
1464-5491
DOI:10.1111/dme.14711