Blood vessels sense dermal stiffness via a novel mechanotransducer, APJ

Microvascular dysfunction accompanied by a dramatic alteration of stable capillary structure is a major hallmark of numerous age-related diseases. In skin, although the role of angiogenesis during dermal reconstitution is well documented, the functional relevance of the extracellular matrix (ECM) st...

Full description

Saved in:
Bibliographic Details
Published in:Angiogenesis (London) 2022-05, Vol.25 (2), p.151-154
Main Authors: Sawane, Mika, Ogura, Yuki, Nakamura, Ayano, Otaka, Hitomi, Kidoya, Hiroyasu, Sato, Katsujiro, Takakura, Nobuyuki, Kajiya, Kentaro
Format: Article
Language:English
Subjects:
Age related diseases
Aging
Angiogenesis
Biomedical and Life Sciences
Biomedicine
Blood Vessels
Cancer Research
Capillaries
Cardiology
Cell Biology
Extracellular matrix
Extracellular Matrix - metabolism
Humans
Letter
Maturation
Microvasculature
Molecular modelling
Neovascularization, Pathologic - metabolism
Oncology
Ophthalmology
Skin - blood supply
Skin diseases
Stiffness
Three dimensional models
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Microvascular dysfunction accompanied by a dramatic alteration of stable capillary structure is a major hallmark of numerous age-related diseases. In skin, although the role of angiogenesis during dermal reconstitution is well documented, the functional relevance of the extracellular matrix (ECM) stiffness to vascular remodeling and its molecular mechanisms was poorly understood. Here, we developed an ex vivo 3-dimensional angiogenic model using human fat, revealing that “appropriate” stiffness induces vascular maturation associated with upregulated APJ expression, whereas the overexpression of APJ promotes the formation of large vessels even in the absence of the “appropriate” stiffness. Taken together, APJ could be a novel mechanotransducer that accelerates the maturation of cutaneous blood vessels, leading to the prevention of human skin aging.
ISSN:0969-6970
1573-7209
DOI:10.1007/s10456-021-09821-6