Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis

Liver vessel density can be evaluated by DDVD (diffusion derived vessel density): DDVD(b0b1) = Sb0/ROIarea0 – Sb1/ROIarea1, where Sb0 and Sb1 refer to the liver signal when b is 0 or 1 s/mm2. Sb1 and ROIarea1 may be replaced by other b-values. With a rat biliary duct ligation (BDL) model, this study...

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Bibliographic Details
Published in:Magnetic resonance imaging 2021-12, Vol.84, p.115-123
Main Authors: Hu, Gen-Wen, Zheng, Cun-Jing, Zhong, Wei-Xiang, Zhuang, Dan-Ping, Xiao, Ben-Heng, Wáng, Yì Xiáng J.
Format: Article
Language:English
Subjects:
Animals
Biliary duct ligation
Diffusion Magnetic Resonance Imaging - methods
Fibrosis
Intravoxel incoherent motion (IVIM)
Liver
Liver - diagnostic imaging
Liver - pathology
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - pathology
Magnetic resonance imaging (MRI)
Male
Motion
Rats
Rats, Sprague-Dawley
Reproducibility of Results
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Summary:Liver vessel density can be evaluated by DDVD (diffusion derived vessel density): DDVD(b0b1) = Sb0/ROIarea0 – Sb1/ROIarea1, where Sb0 and Sb1 refer to the liver signal when b is 0 or 1 s/mm2. Sb1 and ROIarea1 may be replaced by other b-values. With a rat biliary duct ligation (BDL) model, this study assesses the usefulness of liver DDVD computed from a simplified IVIM imaging protocol using b = 25 and b = 50 to replace b = 1 s/mm2, alone and in combination with other IVIM parameters. Male Sprague-Dawley rats were used. The rat number was 5, 5, 5, and 3 respectively, for the timepoints of 7, 14, 21, 28 days post-BDL surgery. 12 rats had partial biliary duct recanalization performed after the rats had BDL for 7 days and then again followed-up for a mean of 14 days. Liver diffusion MRIs were acquired at 3.0 T with a b-value distribution of 0, 25, 50, 75, 100, 150, 300, 700, 1000 s/mm2. DDVDmean (control rats n = 6) was the mean of DDVD(b0b25) and DDVD(b0b50). IVIM fitting started from b = 0 s/mm2 with segmented fitting and a threshold b of 50 s/mm2 (n = 5 for control rats). Three 3-D spaces were constructed using a combination of the four diffusion parameters. The control rats and BDL rats (n = 18) had a liver DDVDmean of 84.0 ± 26.2 and 44.7 ± 14.4 au/pixel (p 
ISSN:0730-725X
1873-5894
DOI:10.1016/j.mri.2021.09.013