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Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis
Liver vessel density can be evaluated by DDVD (diffusion derived vessel density): DDVD(b0b1) = Sb0/ROIarea0 – Sb1/ROIarea1, where Sb0 and Sb1 refer to the liver signal when b is 0 or 1 s/mm2. Sb1 and ROIarea1 may be replaced by other b-values. With a rat biliary duct ligation (BDL) model, this study...
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| Published in: | Magnetic resonance imaging 2021-12, Vol.84, p.115-123 |
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| container_title | Magnetic resonance imaging |
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| creator | Hu, Gen-Wen Zheng, Cun-Jing Zhong, Wei-Xiang Zhuang, Dan-Ping Xiao, Ben-Heng Wáng, Yì Xiáng J. |
| description | Liver vessel density can be evaluated by DDVD (diffusion derived vessel density): DDVD(b0b1) = Sb0/ROIarea0 – Sb1/ROIarea1, where Sb0 and Sb1 refer to the liver signal when b is 0 or 1 s/mm2. Sb1 and ROIarea1 may be replaced by other b-values. With a rat biliary duct ligation (BDL) model, this study assesses the usefulness of liver DDVD computed from a simplified IVIM imaging protocol using b = 25 and b = 50 to replace b = 1 s/mm2, alone and in combination with other IVIM parameters.
Male Sprague-Dawley rats were used. The rat number was 5, 5, 5, and 3 respectively, for the timepoints of 7, 14, 21, 28 days post-BDL surgery. 12 rats had partial biliary duct recanalization performed after the rats had BDL for 7 days and then again followed-up for a mean of 14 days. Liver diffusion MRIs were acquired at 3.0 T with a b-value distribution of 0, 25, 50, 75, 100, 150, 300, 700, 1000 s/mm2. DDVDmean (control rats n = 6) was the mean of DDVD(b0b25) and DDVD(b0b50). IVIM fitting started from b = 0 s/mm2 with segmented fitting and a threshold b of 50 s/mm2 (n = 5 for control rats). Three 3-D spaces were constructed using a combination of the four diffusion parameters.
The control rats and BDL rats (n = 18) had a liver DDVDmean of 84.0 ± 26.2 and 44.7 ± 14.4 au/pixel (p |
| doi_str_mv | 10.1016/j.mri.2021.09.013 |
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Male Sprague-Dawley rats were used. The rat number was 5, 5, 5, and 3 respectively, for the timepoints of 7, 14, 21, 28 days post-BDL surgery. 12 rats had partial biliary duct recanalization performed after the rats had BDL for 7 days and then again followed-up for a mean of 14 days. Liver diffusion MRIs were acquired at 3.0 T with a b-value distribution of 0, 25, 50, 75, 100, 150, 300, 700, 1000 s/mm2. DDVDmean (control rats n = 6) was the mean of DDVD(b0b25) and DDVD(b0b50). IVIM fitting started from b = 0 s/mm2 with segmented fitting and a threshold b of 50 s/mm2 (n = 5 for control rats). Three 3-D spaces were constructed using a combination of the four diffusion parameters.
The control rats and BDL rats (n = 18) had a liver DDVDmean of 84.0 ± 26.2 and 44.7 ± 14.4 au/pixel (p < 0.001). All 3-D spaces totally separated healthy livers and all fibrotic livers (n = 30, BDL rats and recanalization rats). The mean relative distance between healthy liver cluster and fibrotic liver cluster was 0.331 for PF, Dslow, and Dfast; 0.381 for PF, Dfast, and DDVDmean; and 0.384 for PF, Dslow, and DDVDmean.
A combination of PF, Dslow, and Dfast allows total separation of healthy livers and fibrotic livers and the integration of DDVD improved the separation.
•Rat biliary duct ligation shows healthy rat livers have higher DDVD (diffusion derived vessel density) than fibrotic livers.•A DDVD threshold of 57.88 au/pixel offers a sensitivity of 86.7% and a specificity of 100% for separating healthy rat livers and fibrotic rat livers.•IVIM parameters allows a separation of healthy livers and fibrotic livers and integration of DDVD improves the separation.</description><identifier>ISSN: 0730-725X</identifier><identifier>EISSN: 1873-5894</identifier><identifier>DOI: 10.1016/j.mri.2021.09.013</identifier><identifier>PMID: 34619291</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Biliary duct ligation ; Diffusion Magnetic Resonance Imaging - methods ; Fibrosis ; Intravoxel incoherent motion (IVIM) ; Liver ; Liver - diagnostic imaging ; Liver - pathology ; Liver Cirrhosis - diagnostic imaging ; Liver Cirrhosis - pathology ; Magnetic resonance imaging (MRI) ; Male ; Motion ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results</subject><ispartof>Magnetic resonance imaging, 2021-12, Vol.84, p.115-123</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-655c6d3dc37cfcbd39b99c32bae1ed4b4a9e93d5288e6fbe24ce2b3ce409450a3</citedby><cites>FETCH-LOGICAL-c396t-655c6d3dc37cfcbd39b99c32bae1ed4b4a9e93d5288e6fbe24ce2b3ce409450a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34619291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Gen-Wen</creatorcontrib><creatorcontrib>Zheng, Cun-Jing</creatorcontrib><creatorcontrib>Zhong, Wei-Xiang</creatorcontrib><creatorcontrib>Zhuang, Dan-Ping</creatorcontrib><creatorcontrib>Xiao, Ben-Heng</creatorcontrib><creatorcontrib>Wáng, Yì Xiáng J.</creatorcontrib><title>Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis</title><title>Magnetic resonance imaging</title><addtitle>Magn Reson Imaging</addtitle><description>Liver vessel density can be evaluated by DDVD (diffusion derived vessel density): DDVD(b0b1) = Sb0/ROIarea0 – Sb1/ROIarea1, where Sb0 and Sb1 refer to the liver signal when b is 0 or 1 s/mm2. Sb1 and ROIarea1 may be replaced by other b-values. With a rat biliary duct ligation (BDL) model, this study assesses the usefulness of liver DDVD computed from a simplified IVIM imaging protocol using b = 25 and b = 50 to replace b = 1 s/mm2, alone and in combination with other IVIM parameters.
Male Sprague-Dawley rats were used. The rat number was 5, 5, 5, and 3 respectively, for the timepoints of 7, 14, 21, 28 days post-BDL surgery. 12 rats had partial biliary duct recanalization performed after the rats had BDL for 7 days and then again followed-up for a mean of 14 days. Liver diffusion MRIs were acquired at 3.0 T with a b-value distribution of 0, 25, 50, 75, 100, 150, 300, 700, 1000 s/mm2. DDVDmean (control rats n = 6) was the mean of DDVD(b0b25) and DDVD(b0b50). IVIM fitting started from b = 0 s/mm2 with segmented fitting and a threshold b of 50 s/mm2 (n = 5 for control rats). Three 3-D spaces were constructed using a combination of the four diffusion parameters.
The control rats and BDL rats (n = 18) had a liver DDVDmean of 84.0 ± 26.2 and 44.7 ± 14.4 au/pixel (p < 0.001). All 3-D spaces totally separated healthy livers and all fibrotic livers (n = 30, BDL rats and recanalization rats). The mean relative distance between healthy liver cluster and fibrotic liver cluster was 0.331 for PF, Dslow, and Dfast; 0.381 for PF, Dfast, and DDVDmean; and 0.384 for PF, Dslow, and DDVDmean.
A combination of PF, Dslow, and Dfast allows total separation of healthy livers and fibrotic livers and the integration of DDVD improved the separation.
•Rat biliary duct ligation shows healthy rat livers have higher DDVD (diffusion derived vessel density) than fibrotic livers.•A DDVD threshold of 57.88 au/pixel offers a sensitivity of 86.7% and a specificity of 100% for separating healthy rat livers and fibrotic rat livers.•IVIM parameters allows a separation of healthy livers and fibrotic livers and integration of DDVD improves the separation.</description><subject>Animals</subject><subject>Biliary duct ligation</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>Fibrosis</subject><subject>Intravoxel incoherent motion (IVIM)</subject><subject>Liver</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>Liver Cirrhosis - pathology</subject><subject>Magnetic resonance imaging (MRI)</subject><subject>Male</subject><subject>Motion</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reproducibility of Results</subject><issn>0730-725X</issn><issn>1873-5894</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UcGO0zAQtRCI7RY-gAvykUuCHSdpDKfVCthKi7iwiJvl2OMyxYmL7RT6T3wkXnXhyGE0euM3T_P8CHnBWc0Z71_v6yli3bCG10zWjItHZMWHjai6QbaPyYptBKs2Tff1glymtGeMdY3onpIL0fZcNpKvyO-7BG7xM6REg6MWnVsShplaiHgES4_lBXyBc8J8oiZMhyWXuYthopomnA4eHZbJ9sv2I8VJ73De0UMMOZjg39CrmcKvQ1GbYM7a05QXe6I_MX-jUWc6okcdT9QupgAfzHe9A4pzwUXTlxsidTjGkDA9I0-c9gmeP_Q1uXv_7vP1TXX76cP2-uq2MkL2ueq7zvRWWCM2xpnRCjlKaUQzauBg27HVEqSwXTMM0LsRmtZAMwoDLZNtx7RYk1dn3eLixwIpqwmTAe_1DGFJqukG1kvBS60JP1NNuTBFcOpQnBZDijN1H5LaqxKSug9JMalKSGXn5YP8Mk5g_238TaUQ3p4JUEweEaJKBmEuH4IRTFY24H_k_wDoMqfi</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Hu, Gen-Wen</creator><creator>Zheng, Cun-Jing</creator><creator>Zhong, Wei-Xiang</creator><creator>Zhuang, Dan-Ping</creator><creator>Xiao, Ben-Heng</creator><creator>Wáng, Yì Xiáng J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202112</creationdate><title>Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis</title><author>Hu, Gen-Wen ; Zheng, Cun-Jing ; Zhong, Wei-Xiang ; Zhuang, Dan-Ping ; Xiao, Ben-Heng ; Wáng, Yì Xiáng J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-655c6d3dc37cfcbd39b99c32bae1ed4b4a9e93d5288e6fbe24ce2b3ce409450a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biliary duct ligation</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>Fibrosis</topic><topic>Intravoxel incoherent motion (IVIM)</topic><topic>Liver</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>Liver Cirrhosis - pathology</topic><topic>Magnetic resonance imaging (MRI)</topic><topic>Male</topic><topic>Motion</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reproducibility of Results</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Gen-Wen</creatorcontrib><creatorcontrib>Zheng, Cun-Jing</creatorcontrib><creatorcontrib>Zhong, Wei-Xiang</creatorcontrib><creatorcontrib>Zhuang, Dan-Ping</creatorcontrib><creatorcontrib>Xiao, Ben-Heng</creatorcontrib><creatorcontrib>Wáng, Yì Xiáng J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Gen-Wen</au><au>Zheng, Cun-Jing</au><au>Zhong, Wei-Xiang</au><au>Zhuang, Dan-Ping</au><au>Xiao, Ben-Heng</au><au>Wáng, Yì Xiáng J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis</atitle><jtitle>Magnetic resonance imaging</jtitle><addtitle>Magn Reson Imaging</addtitle><date>2021-12</date><risdate>2021</risdate><volume>84</volume><spage>115</spage><epage>123</epage><pages>115-123</pages><issn>0730-725X</issn><eissn>1873-5894</eissn><abstract>Liver vessel density can be evaluated by DDVD (diffusion derived vessel density): DDVD(b0b1) = Sb0/ROIarea0 – Sb1/ROIarea1, where Sb0 and Sb1 refer to the liver signal when b is 0 or 1 s/mm2. Sb1 and ROIarea1 may be replaced by other b-values. With a rat biliary duct ligation (BDL) model, this study assesses the usefulness of liver DDVD computed from a simplified IVIM imaging protocol using b = 25 and b = 50 to replace b = 1 s/mm2, alone and in combination with other IVIM parameters.
Male Sprague-Dawley rats were used. The rat number was 5, 5, 5, and 3 respectively, for the timepoints of 7, 14, 21, 28 days post-BDL surgery. 12 rats had partial biliary duct recanalization performed after the rats had BDL for 7 days and then again followed-up for a mean of 14 days. Liver diffusion MRIs were acquired at 3.0 T with a b-value distribution of 0, 25, 50, 75, 100, 150, 300, 700, 1000 s/mm2. DDVDmean (control rats n = 6) was the mean of DDVD(b0b25) and DDVD(b0b50). IVIM fitting started from b = 0 s/mm2 with segmented fitting and a threshold b of 50 s/mm2 (n = 5 for control rats). Three 3-D spaces were constructed using a combination of the four diffusion parameters.
The control rats and BDL rats (n = 18) had a liver DDVDmean of 84.0 ± 26.2 and 44.7 ± 14.4 au/pixel (p < 0.001). All 3-D spaces totally separated healthy livers and all fibrotic livers (n = 30, BDL rats and recanalization rats). The mean relative distance between healthy liver cluster and fibrotic liver cluster was 0.331 for PF, Dslow, and Dfast; 0.381 for PF, Dfast, and DDVDmean; and 0.384 for PF, Dslow, and DDVDmean.
A combination of PF, Dslow, and Dfast allows total separation of healthy livers and fibrotic livers and the integration of DDVD improved the separation.
•Rat biliary duct ligation shows healthy rat livers have higher DDVD (diffusion derived vessel density) than fibrotic livers.•A DDVD threshold of 57.88 au/pixel offers a sensitivity of 86.7% and a specificity of 100% for separating healthy rat livers and fibrotic rat livers.•IVIM parameters allows a separation of healthy livers and fibrotic livers and integration of DDVD improves the separation.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>34619291</pmid><doi>10.1016/j.mri.2021.09.013</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biliary duct ligation Diffusion Magnetic Resonance Imaging - methods Fibrosis Intravoxel incoherent motion (IVIM) Liver Liver - diagnostic imaging Liver - pathology Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - pathology Magnetic resonance imaging (MRI) Male Motion Rats Rats, Sprague-Dawley Reproducibility of Results |
| title | Usefulness of diffusion derived vessel density computed from a simplified IVIM imaging protocol: An experimental study with rat biliary duct blockage induced liver fibrosis |
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