microRNA-10b promotes the apoptosis of bovine ovarian granulosa cells by targeting plasminogen activator inhibitor-1

Granulosa cells (GCs) are essential somatic cells in the ovaries, and apoptosis of GCs causes follicular atresia. microRNA-10b (miR-10b) is pivotal for cell apoptosis. However, currently, little is known about the role of miR-10b in bovine ovarian GCs (BGCs). In this study, the effect of miR-10b on...

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Bibliographic Details
Published in:Theriogenology 2021-12, Vol.176, p.206-216
Main Authors: Guo, Lewei, Huang, Qixuan, Zhao, Jing, Liu, Hongyu, Lu, Wenfa, Wang, Jun
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Bovine granulosa cell
Cattle
Cell Proliferation
Female
Follicular Atresia
Granulosa Cells
MicroRNAs - genetics
miR-10b
PAI-1
Phosphatidylinositol 3-Kinases
Plasminogen Activator Inhibitor 1 - genetics
Proto-Oncogene Proteins c-akt
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Summary:Granulosa cells (GCs) are essential somatic cells in the ovaries, and apoptosis of GCs causes follicular atresia. microRNA-10b (miR-10b) is pivotal for cell apoptosis. However, currently, little is known about the role of miR-10b in bovine ovarian GCs (BGCs). In this study, the effect of miR-10b on the apoptosis of BGCs was investigated. Our results showed that the overexpression of miR-10b could increase the apoptosis rate of BGCs, which is associated with the increased expression of Caspase-3 and decreased expression ratio of Bcl-2/Bax (P 
ISSN:0093-691X
1879-3231
DOI:10.1016/j.theriogenology.2021.09.035