Salivary cytokines levels, maternal periodontitis and infants' weight at birth: A cohort study in pregnant women with obesity

Obesity and pregnancy may have synergistic effects on maternal periodontal tissues. In contrast, maternal obesity and periodontitis are antagonistic factors for the babies' weight at birth. This study evaluated, during pregnancy (T1) and after delivery (T2), periodontal parameters and salivary...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2021-11, Vol.115, p.151-157
Main Authors: Foratori-Junior, Gerson Aparecido, Mosquim, Victor, Buzalaf, Marília Afonso Rabelo, Sales-Peres, Silvia Helena de Carvalho
Format: Article
Language:English
Subjects:
Birth Weight - physiology
Body Mass Index
Cohort Studies
Cytokines
Cytokines - analysis
Female
Humans
Infant, Low Birth Weight
Infant, Newborn
Interleukin-1beta - analysis
Leptin - analysis
Obesity - complications
Obesity - epidemiology
Periodontitis
Periodontitis - complications
Periodontitis - epidemiology
Pregnancy
Pregnancy complications
Pregnancy Complications - physiopathology
Saliva - chemistry
Tumor Necrosis Factor-alpha - analysis
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Summary:Obesity and pregnancy may have synergistic effects on maternal periodontal tissues. In contrast, maternal obesity and periodontitis are antagonistic factors for the babies' weight at birth. This study evaluated, during pregnancy (T1) and after delivery (T2), periodontal parameters and salivary levels of cytokines in women with obesity, and the association of these outcomes with the baby's weight at birth. After matching by age, socioeconomic status and systemic health, the sample was composed of pregnant women with obesity (GO = 25; BMI ≥30 kg/m2) and normal BMI (GN = 25; BMI between 18.5 and 24.99 kg/m2), who were evaluated regarding: periodontal parameters; salivary levels of TNF-α, IL-1β and leptin (Luminex® assay); and babies' weight at birth. Mann-Whitney, Friedman, ANOVA; chi-square and Cochran's Q tests were applied (p 
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2021.09.018