Radical Transformation of Aliphatic C–H Bonds to Oxime Ethers via Hydrogen Atom Transfer

Herein, we describe a strategy for conversion of aliphatic C–H bonds to oxime ethers via hydrogen atom transfer. In this strategy, the decatungstate anion and sulfate radical play complementary roles in the abstraction of hydrogen atoms from primary, secondary, and tertiary C–H bonds of alkanes. The...

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Bibliographic Details
Published in:Organic letters 2021-11, Vol.23 (21), p.8353-8358
Main Authors: Wang, Xinmou, Yu, Mo, Song, Hongjian, Liu, Yuxiu, Wang, Qingmin
Format: Article
Language:English
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Summary:Herein, we describe a strategy for conversion of aliphatic C–H bonds to oxime ethers via hydrogen atom transfer. In this strategy, the decatungstate anion and sulfate radical play complementary roles in the abstraction of hydrogen atoms from primary, secondary, and tertiary C–H bonds of alkanes. The easy accessibility of alkanes and the broad substrate scope, mild conditions, and excellent regioselectivity of these reactions make this strategy applicable for the transformation of raw materials to high-value chemicals.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c03087