The relation of optical coherence tomography findings with oxidative stress parameters in patients with bipolar disorder and unaffected first-degree relatives

• Published in: Journal of affective disorders 2022-01, Vol.296, p.283-290
• Main Authors: Kilicarslan, Tezer, Sahan, Ebru, Kirik, Furkan, Guler, Eray Metin, Kurtulmus, Ayse, Yildiz, Fatma Busra Parlakkaya, Ozdemir, Mehmet Hakan, Kocyigit, Abdurrahim, Kirpinar, Ismet
• Format: Article
• Language: English
• Subjects: Bipolar disorder; Bipolar Disorder - diagnostic imaging; Bipolar Disorder - genetics; Endophenotype; Humans; Optical coherence tomography; Oxidative Stress; Retina; Retinal Ganglion Cells; Tomography, Optical Coherence; Unaffetcted first-degree relatives
• ISSN: 0165-0327; 1573-2517
• DOI: 10.1016/j.jad.2021.09.065

•TOS, TAS, OSI, TT, NT, DIS, HNE can be useful endophenotype biomarkers in BD.•Among the OCT findings, CMT was determined as the closest parameter to being an endophenotype biomarker.•Oxidative stress parameters are more effective than OCT findings in endophenotype studies. We aimed to evaluate the optical coherence tomography(OCT) findings and oxidative stress parameters in patients with bipolar disorder(BD) and their unaffected first-degree relatives(FDRs) and to explore OCT findings and oxidative stress parameters as potential endophenotype candidates. Fifty patients with BD, 40 FDRs of BD, and 50 healthy controls(HCs) were included. OCT was performed to measure peripapillary retinal nerve fiber layer(RNFL), ganglion cell layer(GCL), inner plexiform layer(IPL), central macular, and minimum foveal thicknesses(CMT and MFT), choroidal thickness(ChT). 4-hydroxy-2-nonenal(HNE), total thiol(TT), native thiol(NT), total oxidant status(TOS), total antioxidant status(TAS), disulfide(DIS) and oxidative stress index(OSI) were measured from serum samples. TOS was higher patients with BD and FDRs than HCs (p