The normalized limit of detection in NMR spectroscopy

[Display omitted] •Discussion of NMR SNR in time-domain and frequency-domain.•New limit of detection equation for frequency domain.•Sensitivity comparison of microcoils.•Standard format for sensitivity measurements and publications for new NMR systems. We derive the normalized limit of detection for...

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Bibliographic Details
Published in:Journal of magnetic resonance (1997) 2021-11, Vol.332, p.107077-107077, Article 107077
Main Authors: Lepucki, Piotr, Dioguardi, Adam P., Karnaushenko, Daniil, Schmidt, Oliver G., Grafe, Hans-Joachim
Format: Article
Language:English
Subjects:
Limit of detection
Microcoil
Nuclear magnetic resonance
Signal-to-noise ratio SNR
Spectroscopy
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Summary:[Display omitted] •Discussion of NMR SNR in time-domain and frequency-domain.•New limit of detection equation for frequency domain.•Sensitivity comparison of microcoils.•Standard format for sensitivity measurements and publications for new NMR systems. We derive the normalized limit of detection for frequency space (nLODf) as a parameter to measure the sensitivity of an NMR spectroscopy setup. nLODf is independent of measurement settings such as bandwidth or number of measurement points, and allows to compare performances of different setups. We demonstrate the usefulness of the new nLODf by comparing the sensitivity of NMR setups from various publications, which all use microcoils. Finally, we want to propose a standard measurement and report format for the sensitivity of new NMR setups.
ISSN:1090-7807
1096-0856
DOI:10.1016/j.jmr.2021.107077