Selective detection of enrofloxacin in biological and environmental samples using a molecularly imprinted electrochemiluminescence sensor based on functionalized copper nanoclusters

Enrofloxacin (ENR) is a broad-spectrum fungicide that has been largely applied in pharmacy and animal-specific medicine. In this paper, a simple, novel and highly sensitive molecularly imprinted electrochemiluminescence (MIP-ECL) sensor based on mercaptopropionic acid-functionalized copper nanoclust...

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Bibliographic Details
Published in:Talanta (Oxford) 2022-01, Vol.236, p.122835-122835, Article 122835
Main Authors: Wang, Dawei, Jiang, Shenghao, Liang, Yuanyuan, Wang, Xiaobin, Zhuang, Xuming, Tian, Chunyuan, Luan, Feng, Chen, Lingxin
Format: Article
Language:English
Subjects:
Copper nanoclusters
Electrochemiluminescence
Enrofloxacin
Molecular imprinting
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Summary:Enrofloxacin (ENR) is a broad-spectrum fungicide that has been largely applied in pharmacy and animal-specific medicine. In this paper, a simple, novel and highly sensitive molecularly imprinted electrochemiluminescence (MIP-ECL) sensor based on mercaptopropionic acid-functionalized copper nanoclusters (MPA-Cu NCs) was developed to selectively detect enrofloxacin (ENR). MPA-Cu NCs prepared by a one-step method were used to modify the glassy carbon electrode. A molecularly imprinted polymer film containing the cavity was constructed after electropolymerization and elution. Under optimized conditions, the MIP-ECL sensor could detect ENR in the range of 0.1 nM–1 μM (R2 = 0.9863) with a low limit of detection of 27 pM, and the recovery rates of ENR in biological and lake water samples were 88.20–105.0%. The MIP-ECL sensor provided path to improve the stability issues of Cu NCs, which might open promising avenues to develop new ECL systems for biological analysis and environmental water monitoring. [Display omitted] •A molecularly imprinted electrochemiluminescence (MIP-ECL) sensor based on copper nanoclusters was constructed.•Functionalized copper nanoclusters with an excellent enrofloxacin ECL signal were prepared by one-step redox method.•The MIP-ECL system specifically recognizes enrofloxacin with low limit of detection at 27 pM.•The sensor was successfully applied to trace detection of enrofloxacin in biological and environmental water samples.
ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2021.122835