Efficacy of intravitreal povidone-iodine administration for the treatment of Candida albicans endophthalmitis in rabbits

This study aimed to investigate the efficacy of intravitreal povidone-iodine (PI) administration for the treatment of Candida albicans endophthalmitis. Forty New Zealand white rabbits were divided into four groups (n = 10 per group). After the induction of endophthalmitis using Candida albicans, gro...

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Bibliographic Details
Published in:Experimental eye research 2021-11, Vol.212, p.108788-108788, Article 108788
Main Authors: Lee, Seung Min, Park, Jong Ho, Suh, Su Youn, Lee, Sang Min, Byon, Iksoo
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents, Local - administration & dosage
Candida albicans
Candida albicans - isolation & purification
Candidiasis - drug therapy
Candidiasis - microbiology
Disease Models, Animal
Endophthalmitis
Endophthalmitis - drug therapy
Endophthalmitis - microbiology
Eye Infections, Fungal - drug therapy
Eye Infections, Fungal - microbiology
Female
Intravitreal Injections
Povidone-iodine
Povidone-Iodine - administration & dosage
Rabbit
Rabbits
Voriconazole
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Summary:This study aimed to investigate the efficacy of intravitreal povidone-iodine (PI) administration for the treatment of Candida albicans endophthalmitis. Forty New Zealand white rabbits were divided into four groups (n = 10 per group). After the induction of endophthalmitis using Candida albicans, groups A, B, and C received single intravitreal injections of 0.035 mg voriconazole, 0.3 mg PI, and their combination, respectively. Rabbits that were administered sham injections were in group D as controls. Fundus photography, vitreous culture, electroretinography (ERG), and histologic examinations of the retina were conducted on day 7. The anterior chamber flare (grade 0 to 4), severity of iritis (grade 0 to 4), and vitreous opacity (grade 0 to 3) were scored. Candida albicans was cultured in the vitreous sample. On day 7, the vitreous opacities were found in all groups. Compared to that in group D, groups A, B, and C showed a lower score for flare (p 
ISSN:0014-4835
1096-0007
DOI:10.1016/j.exer.2021.108788