Diverse role of endocannabinoid system in mammalian male reproduction

• Published in: Life sciences (1973) 2021-12, Vol.286, p.120035-120035, Article 120035
• Main Authors: Sayed, Tahseen S., Balasinor, Nafisa H., Nishi, Kumari
• Format: Article
• Language: English
• Subjects: Animals; Cannabinoids; Cannabinoids - metabolism; Central nervous system; Endocannabinoid system; Endocannabinoids; Endocannabinoids - metabolism; Endocannabinoids - physiology; Fertility; Fertility - drug effects; Genitalia, Male - metabolism; Humans; Immune system; Immune System - metabolism; Lipids; Male; Male reproduction; Males; Prostate - pathology; Prostate cancer; Receptors, Cannabinoid - physiology; Reproduction; Reproduction - drug effects; Reproduction - physiology; Reproductive system; Sexual behavior; Spermatogenesis; Spermatozoa; Spermatozoa - drug effects
• ISSN: 0024-3205; 1879-0631
• DOI: 10.1016/j.lfs.2021.120035

Endocannabinoid system (ECS) is known for its modulatory role in numerous physiological processes in the body. Endocannabinoids (eCBs) are endogenous lipid molecules which function both centrally and peripherally. The ECS is best studied in the central nervous system (CNS), immune system as well as in the metabolic system. The role of ECS in male reproductive system is emerging and the presence of a complete enzymatic machinery to synthesize and metabolize eCBs has been demonstrated in male reproductive tract. Endocannabinoid concentrations and alterations in their levels have been reported to affect the functioning of spermatozoa. A dysfunctional ECS has also been linked to the development of prostate cancer, the leading cause of cancer related mortality among male population. This review is an attempt to provide an insight into the significant role of endocannabinoids in male reproduction and further summarize recent findings that demonstrate the manner in which the endocannabinoid system impacts male sexual behavior and fertility. [Display omitted]