Diagnosis and Clinical Development of Sporadic Inclusion Body Myositis and Polymyositis With Mitochondrial Pathology: A Single-Center Retrospective Analysis

Abstract To review our diagnostic and treatment approaches concerning sporadic inclusion body myositis (sIBM) and polymyositis with mitochondrial pathology (PM-Mito), we conducted a retrospective analysis of clinical and histological data of 32 patients diagnosed as sIBM and 7 patients diagnosed as...

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Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 2021-11, Vol.80 (11), p.1060-1067
Main Authors: Winkler, Maren, von Landenberg, Christina, Kappes-Horn, Karin, Neudecker, Stephan, Kornblum, Cornelia, Reimann, Jens
Format: Article
Language:English
Subjects:
Adenosine triphosphatase
Aged
Biopsy
Care and treatment
Cytotoxicity
Development and progression
Diagnosis
Diagnosis, Differential
Disease Progression
Female
Histology
Humans
Immunosuppressive Agents - therapeutic use
Immunotherapy
Inclusion body myositis
Inflammatory diseases
Laboratories
Male
Middle Aged
Mitochondria - pathology
Mitochondrial diseases
Mitochondrial DNA
Muscle, Skeletal - pathology
Musculoskeletal diseases
Myositis
Myositis, Inclusion Body - diagnosis
Myositis, Inclusion Body - drug therapy
Myositis, Inclusion Body - pathology
Neurology
Neuromuscular diseases
Organ Transplantation
Pathology
Polymyositis
Polymyositis - drug therapy
Polymyositis - pathology
Proteins
Retrospective Studies
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Summary:Abstract To review our diagnostic and treatment approaches concerning sporadic inclusion body myositis (sIBM) and polymyositis with mitochondrial pathology (PM-Mito), we conducted a retrospective analysis of clinical and histological data of 32 patients diagnosed as sIBM and 7 patients diagnosed as PM-Mito by muscle biopsy. Of 32 patients identified histologically as sIBM, 19 fulfilled the 2011 European Neuromuscular Center (ENMC) diagnostic criteria for “clinico-pathologically defined sIBM” at the time of biopsy. Among these, 2 patients developed sIBM after years of immunosuppressive treatment for organ transplantation. Of 11 patients fulfilling the histological but not the clinical criteria, including 3 cases with duration
ISSN:0022-3069
1554-6578
DOI:10.1093/jnen/nlab101