Pharmacological basis and new insights of deguelin concerning its anticancer effects

• Published in: Pharmacological research 2021-12, Vol.174, p.105935-105935, Article 105935
• Main Authors: Lin, Zhu Yue, Yun, Qu Zhen, Wu, Liu, Zhang, Tian Wen, Yao, Tang Ze
• Format: Article
• Language: English
• Subjects: Animals; Anticancer; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - therapeutic use; Apoptosis; Apoptosis - drug effects; Autophagy - drug effects; Cell Cycle - drug effects; Deguelin; Humans; Neoplasm Metastasis; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; NF-κB signaling pathway; Nucleophosmin - genetics; PI3K/Akt signaling pathway; Rotenone - analogs & derivatives; Rotenone - pharmacology; Rotenone - therapeutic use; Wnt signaling pathway
• ISSN: 1043-6618; 1096-1186
• DOI: 10.1016/j.phrs.2021.105935

Deguelin is a rotenoid of the flavonoid family, which can be extracted from Lonchocarpus, Derris, or Tephrosia. It possesses the inhibition of cancer cell proliferation by inducing apoptosis through regulating the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, the NF-κB signaling pathway, the Wnt signaling pathway, the adenosine 5‘-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway and epidermal growth factor receptor (EGFR) signaling, activating the p38 mitogen-activated protein kinase (MAPK) pathway, repression of Bmi1, targeting cyclooxygenase-2 (COX-2), targeting galectin-1, promotion of glycogen synthase kinase-3β (GSK3β)/FBW7-mediated Mcl-1 destabilization and targeting mitochondria via down-regulating Hexokinases II-mediated glycolysis, PUMA-mediation, which are some crucial molecules which modulate closely cancer cell growth and metastasis. Deguelin inhibits tumor cell propagation and malignant transformation through targeting angiogenesis, targeting lymphangiogenesis, targeting focal adhesion kinase (FAK), inhibiting the CtsZ/FAK signaling pathway, targeting epithelial–mesenchymal transition (EMT), the NF-κB signaling pathway, regulating NIMA-related kinase 2 (NEK2). In addition, deguelin possesses other biological activities, such as targeting cell cycle arrest, modulation of autophagy, inhibition of hedgehog pathway, inducing differentiation of mutated NPM1 acute myeloid leukemia etc. Therefore, deguelin is a promising chemopreventive agent for cancer therapy. Anticancer activity of deguelin and its derivatives: recent advances in mechanisms of action (AMPK: Adenosine 5‘-monophosphate (AMP)-activated protein kinase; COX-2: Cyclooxygenase; EGFR: Epidermal growth factor receptor; EMT: Epithelial–mesenchymal transition; FAK: Focal adhesion kinase; GSK3β: Glycogen synthase kinase-3; Hh: Hedgehog; MAPK: p38 mitogen-activated protein kinase; NF-κB: Nuclear factor κB; PI3K/Akt: Phosphoinositide 3-kinase/protein kinase B). [Display omitted]