High Intensity Physical Exercise before the Brain Ischemia Promotes Increase in Brain Injury

Studies have demonstrated the beneficial effects of light- and moderate-intensity physical exercise on the nervous system of animals with cerebral ischemia. To investigate the effects of two high-intensity physical exercise protocols, standardized for resistance and strength gain, in rats trained be...

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Published in:Journal of stroke and cerebrovascular diseases 2021-12, Vol.30 (12), p.106148-106148, Article 106148
Main Authors: Vasconcelos, Nathália Nascimento, Pereira, Luan Alves, Silva, Regina Suzette Rodrigues, Dias, Karine Sthéfany Serpa Amaral, Mourão, Thiago Silveira, Pereira, Liliane Costa, Cota, Vinícius Rosa, Pinto, Flávia Carmo Horta, Damázio, Laila Cristina Moreira
Format: Article
Language:English
Subjects:
Animals
Brain Injuries - epidemiology
Brain ischemia
Brain Ischemia - etiology
Carotid Artery Diseases - complications
Cerebrovascular circulation
Endurance training
Exercise
Hypertrophy left ventricular
Male
Muscle strength
Neurons
Neuroprotection
Physical Conditioning, Animal - adverse effects
Physical Conditioning, Animal - physiology
Rats
Rats, Wistar
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Summary:Studies have demonstrated the beneficial effects of light- and moderate-intensity physical exercise on the nervous system of animals with cerebral ischemia. To investigate the effects of two high-intensity physical exercise protocols, standardized for resistance and strength gain, in rats trained before cerebral ischemia induced by Bilateral Common Carotid Artery Occlusion (BCCAO). Forty-eight male Wistar rats were divided into two groups: with ischemia and without ischemia (sham). Both groups were subdivided into animals that performed high-intensity exercises in the muscle strength modality (I+Ex2; Sham+Ex2; n=16); animals submitted to high-intensity exercises in the aerobic modality (I+Ex1; Sham+Ex1; n=16), and animals that did not practice physical exercises - sedentary (I+Sed; Sham+Sed, n=16). Cerebral ischemia was induced using the BCCAO model. The physical training program used before the procedure was of high intensity, in the aerobic and muscular strength modalities, and was performed using a vertical ladder, for 4 weeks, 5 days per week. In order to process and stain the brain tissue, the Nissl method was used for neuron labeling and quantification in the cortex, striatum, and hippocampus. As for the animals’ body weight and the heart weight differences were found between the groups I+Ex2 and Sham+Ex2 (p
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2021.106148