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12-Month Outcomes of Combined Phacoemulsification and iStent Inject in Asian Eyes with Normal Tension Glaucoma: A Single-Centre Experience
Purpose To evaluate efficacy and safety of the iStent inject combined with phacoemulsification in Asian eyes with normal-tension glaucoma (NTG) up to 12 months after surgery. Study design Retrospective case series. Methods Retrospective case series of eyes undergoing surgery from April 2017 to Augus...
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| Published in: | International ophthalmology 2022-02, Vol.42 (2), p.611-620 |
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| container_title | International ophthalmology |
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| creator | Ang, Bryan C. H. Tecson, Ivan C. R. O’Neill Hu, Jeremy Y. W. Kan, John T. C. Yip, Leonard W. L. |
| description | Purpose
To evaluate efficacy and safety of the iStent inject combined with phacoemulsification in Asian eyes with normal-tension glaucoma (NTG) up to 12 months after surgery.
Study design
Retrospective case series.
Methods
Retrospective case series of eyes undergoing surgery from April 2017 to August 2019. Outcome measures included intraocular pressure (IOP), number of topical glaucoma medications and adverse outcomes. Data were retrieved from the post-operative day 1 (POD1), week 1 (POW1), month 1 (POM1), month 3 (POM3), month 6 (POM6) and month 12 (POM12) timepoints. Data were analysed at each timepoint for eyes with available clinical data at that visit. Subgroup analysis was performed for a consistent cohort which included only eyes with data at all six follow-up timepoints.
Results
Data from 91 eyes in the collective subject group was analysed. Majority of subjects were male (53, 58.2%) and Chinese (79, 86.8%). Mean age was 73.2 ± 7.2 years. Pre-operatively, mean IOP was 14.3 ± 3.0 mmHg and mean number of medications was 1.5 ± 0.8. Significant IOP reduction was observed at all timepoints except POW1 and POM12. The number of medications was reduced at all timepoints (
p
|
| doi_str_mv | 10.1007/s10792-021-02033-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2582806659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2633579410</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-65bf056ec932b30a9381c16708e59e052930985a77a687428d2bc483cf86b1363</originalsourceid><addsrcrecordid>eNp9kUFvFCEYhonR2G31D3gwJF68jH7AAoO3zWatTao1aT0Thv2mZTMDK8yk9i_4q0vdqokHD-Q78LzPR3gJecXgHQPQ7wsDbXgDnNUDQjTiCVkwqUXDlYCnZAFMyUZqYEfkuJQdABht1HNyJJZKcrmUC_KT8eZzitMNvZgnn0YsNPV0ncYuRNzSrzfOJxznoYQ-eDeFFKmLWxouJ4wTPYs79BMNka5KcJFu7mr-NlTbl5RHN9ArjOUhczq4udrdB7qilyFeD9isqyAj3fzYYw4YPb4gz3o3FHz5OE_It4-bq_Wn5vzi9Gy9Om-80HJqlOx6kAq9EbwT4IxomWdKQ4vSIEhuBJhWOq2davWSt1ve-WUrfN-qjgklTsjbg3ef0_cZy2THUDwOg4uY5mK5bHkLSklT0Tf_oLs051hfZ-sXC6nNkkGl-IHyOZWSsbf7HEaX7ywD-9CUPTRla1P2V1NW1NDrR_Xcjbj9E_ldTQXEASj1Kl5j_rv7P9p7GmGc1w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2633579410</pqid></control><display><type>article</type><title>12-Month Outcomes of Combined Phacoemulsification and iStent Inject in Asian Eyes with Normal Tension Glaucoma: A Single-Centre Experience</title><source>Springer Nature</source><creator>Ang, Bryan C. H. ; Tecson, Ivan C. R. O’Neill ; Hu, Jeremy Y. W. ; Kan, John T. C. ; Yip, Leonard W. L.</creator><creatorcontrib>Ang, Bryan C. H. ; Tecson, Ivan C. R. O’Neill ; Hu, Jeremy Y. W. ; Kan, John T. C. ; Yip, Leonard W. L.</creatorcontrib><description>Purpose
To evaluate efficacy and safety of the iStent inject combined with phacoemulsification in Asian eyes with normal-tension glaucoma (NTG) up to 12 months after surgery.
Study design
Retrospective case series.
Methods
Retrospective case series of eyes undergoing surgery from April 2017 to August 2019. Outcome measures included intraocular pressure (IOP), number of topical glaucoma medications and adverse outcomes. Data were retrieved from the post-operative day 1 (POD1), week 1 (POW1), month 1 (POM1), month 3 (POM3), month 6 (POM6) and month 12 (POM12) timepoints. Data were analysed at each timepoint for eyes with available clinical data at that visit. Subgroup analysis was performed for a consistent cohort which included only eyes with data at all six follow-up timepoints.
Results
Data from 91 eyes in the collective subject group was analysed. Majority of subjects were male (53, 58.2%) and Chinese (79, 86.8%). Mean age was 73.2 ± 7.2 years. Pre-operatively, mean IOP was 14.3 ± 3.0 mmHg and mean number of medications was 1.5 ± 0.8. Significant IOP reduction was observed at all timepoints except POW1 and POM12. The number of medications was reduced at all timepoints (
p
< 0.001). By POM12, there was reduction of 1.2 ± 1.0 medications (
p
< 0.001). Both the collective and consistent cohorts demonstrated a trend towards decreasing surgical efficacy with time, in IOP reduction and decrease in medications. None of the eyes experienced sight-threatening complications.
Conclusions
Asian eyes with NTG undergoing combined phacoemulsification and iStent inject surgery demonstrated significant and sustained reduction in number of glaucoma medications up to 12 months post-operatively.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-021-02033-3</identifier><identifier>PMID: 34652545</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Aged ; Aged, 80 and over ; Complications ; Eye ; Eye (anatomy) ; Eye surgery ; Female ; Glaucoma ; Glaucoma, Open-Angle - surgery ; Humans ; Intraocular Pressure ; Low Tension Glaucoma - surgery ; Male ; Medicine ; Medicine & Public Health ; Ophthalmology ; Original Paper ; Phacoemulsification ; Retrospective Studies ; Stents ; Subgroups ; Surgery ; Surgical outcomes ; Trabecular Meshwork - surgery</subject><ispartof>International ophthalmology, 2022-02, Vol.42 (2), p.611-620</ispartof><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer Nature B.V.</rights><rights>The Author(s), under exclusive licence to Springer Nature B.V. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-65bf056ec932b30a9381c16708e59e052930985a77a687428d2bc483cf86b1363</citedby><cites>FETCH-LOGICAL-c375t-65bf056ec932b30a9381c16708e59e052930985a77a687428d2bc483cf86b1363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34652545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ang, Bryan C. H.</creatorcontrib><creatorcontrib>Tecson, Ivan C. R. O’Neill</creatorcontrib><creatorcontrib>Hu, Jeremy Y. W.</creatorcontrib><creatorcontrib>Kan, John T. C.</creatorcontrib><creatorcontrib>Yip, Leonard W. L.</creatorcontrib><title>12-Month Outcomes of Combined Phacoemulsification and iStent Inject in Asian Eyes with Normal Tension Glaucoma: A Single-Centre Experience</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To evaluate efficacy and safety of the iStent inject combined with phacoemulsification in Asian eyes with normal-tension glaucoma (NTG) up to 12 months after surgery.
Study design
Retrospective case series.
Methods
Retrospective case series of eyes undergoing surgery from April 2017 to August 2019. Outcome measures included intraocular pressure (IOP), number of topical glaucoma medications and adverse outcomes. Data were retrieved from the post-operative day 1 (POD1), week 1 (POW1), month 1 (POM1), month 3 (POM3), month 6 (POM6) and month 12 (POM12) timepoints. Data were analysed at each timepoint for eyes with available clinical data at that visit. Subgroup analysis was performed for a consistent cohort which included only eyes with data at all six follow-up timepoints.
Results
Data from 91 eyes in the collective subject group was analysed. Majority of subjects were male (53, 58.2%) and Chinese (79, 86.8%). Mean age was 73.2 ± 7.2 years. Pre-operatively, mean IOP was 14.3 ± 3.0 mmHg and mean number of medications was 1.5 ± 0.8. Significant IOP reduction was observed at all timepoints except POW1 and POM12. The number of medications was reduced at all timepoints (
p
< 0.001). By POM12, there was reduction of 1.2 ± 1.0 medications (
p
< 0.001). Both the collective and consistent cohorts demonstrated a trend towards decreasing surgical efficacy with time, in IOP reduction and decrease in medications. None of the eyes experienced sight-threatening complications.
Conclusions
Asian eyes with NTG undergoing combined phacoemulsification and iStent inject surgery demonstrated significant and sustained reduction in number of glaucoma medications up to 12 months post-operatively.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Complications</subject><subject>Eye</subject><subject>Eye (anatomy)</subject><subject>Eye surgery</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma, Open-Angle - surgery</subject><subject>Humans</subject><subject>Intraocular Pressure</subject><subject>Low Tension Glaucoma - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Original Paper</subject><subject>Phacoemulsification</subject><subject>Retrospective Studies</subject><subject>Stents</subject><subject>Subgroups</subject><subject>Surgery</subject><subject>Surgical outcomes</subject><subject>Trabecular Meshwork - surgery</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kUFvFCEYhonR2G31D3gwJF68jH7AAoO3zWatTao1aT0Thv2mZTMDK8yk9i_4q0vdqokHD-Q78LzPR3gJecXgHQPQ7wsDbXgDnNUDQjTiCVkwqUXDlYCnZAFMyUZqYEfkuJQdABht1HNyJJZKcrmUC_KT8eZzitMNvZgnn0YsNPV0ncYuRNzSrzfOJxznoYQ-eDeFFKmLWxouJ4wTPYs79BMNka5KcJFu7mr-NlTbl5RHN9ArjOUhczq4udrdB7qilyFeD9isqyAj3fzYYw4YPb4gz3o3FHz5OE_It4-bq_Wn5vzi9Gy9Om-80HJqlOx6kAq9EbwT4IxomWdKQ4vSIEhuBJhWOq2davWSt1ve-WUrfN-qjgklTsjbg3ef0_cZy2THUDwOg4uY5mK5bHkLSklT0Tf_oLs051hfZ-sXC6nNkkGl-IHyOZWSsbf7HEaX7ywD-9CUPTRla1P2V1NW1NDrR_Xcjbj9E_ldTQXEASj1Kl5j_rv7P9p7GmGc1w</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Ang, Bryan C. H.</creator><creator>Tecson, Ivan C. R. O’Neill</creator><creator>Hu, Jeremy Y. W.</creator><creator>Kan, John T. C.</creator><creator>Yip, Leonard W. L.</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20220201</creationdate><title>12-Month Outcomes of Combined Phacoemulsification and iStent Inject in Asian Eyes with Normal Tension Glaucoma: A Single-Centre Experience</title><author>Ang, Bryan C. H. ; Tecson, Ivan C. R. O’Neill ; Hu, Jeremy Y. W. ; Kan, John T. C. ; Yip, Leonard W. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-65bf056ec932b30a9381c16708e59e052930985a77a687428d2bc483cf86b1363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Complications</topic><topic>Eye</topic><topic>Eye (anatomy)</topic><topic>Eye surgery</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma, Open-Angle - surgery</topic><topic>Humans</topic><topic>Intraocular Pressure</topic><topic>Low Tension Glaucoma - surgery</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Original Paper</topic><topic>Phacoemulsification</topic><topic>Retrospective Studies</topic><topic>Stents</topic><topic>Subgroups</topic><topic>Surgery</topic><topic>Surgical outcomes</topic><topic>Trabecular Meshwork - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ang, Bryan C. H.</creatorcontrib><creatorcontrib>Tecson, Ivan C. R. O’Neill</creatorcontrib><creatorcontrib>Hu, Jeremy Y. W.</creatorcontrib><creatorcontrib>Kan, John T. C.</creatorcontrib><creatorcontrib>Yip, Leonard W. L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ang, Bryan C. H.</au><au>Tecson, Ivan C. R. O’Neill</au><au>Hu, Jeremy Y. W.</au><au>Kan, John T. C.</au><au>Yip, Leonard W. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>12-Month Outcomes of Combined Phacoemulsification and iStent Inject in Asian Eyes with Normal Tension Glaucoma: A Single-Centre Experience</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>42</volume><issue>2</issue><spage>611</spage><epage>620</epage><pages>611-620</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To evaluate efficacy and safety of the iStent inject combined with phacoemulsification in Asian eyes with normal-tension glaucoma (NTG) up to 12 months after surgery.
Study design
Retrospective case series.
Methods
Retrospective case series of eyes undergoing surgery from April 2017 to August 2019. Outcome measures included intraocular pressure (IOP), number of topical glaucoma medications and adverse outcomes. Data were retrieved from the post-operative day 1 (POD1), week 1 (POW1), month 1 (POM1), month 3 (POM3), month 6 (POM6) and month 12 (POM12) timepoints. Data were analysed at each timepoint for eyes with available clinical data at that visit. Subgroup analysis was performed for a consistent cohort which included only eyes with data at all six follow-up timepoints.
Results
Data from 91 eyes in the collective subject group was analysed. Majority of subjects were male (53, 58.2%) and Chinese (79, 86.8%). Mean age was 73.2 ± 7.2 years. Pre-operatively, mean IOP was 14.3 ± 3.0 mmHg and mean number of medications was 1.5 ± 0.8. Significant IOP reduction was observed at all timepoints except POW1 and POM12. The number of medications was reduced at all timepoints (
p
< 0.001). By POM12, there was reduction of 1.2 ± 1.0 medications (
p
< 0.001). Both the collective and consistent cohorts demonstrated a trend towards decreasing surgical efficacy with time, in IOP reduction and decrease in medications. None of the eyes experienced sight-threatening complications.
Conclusions
Asian eyes with NTG undergoing combined phacoemulsification and iStent inject surgery demonstrated significant and sustained reduction in number of glaucoma medications up to 12 months post-operatively.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>34652545</pmid><doi>10.1007/s10792-021-02033-3</doi><tpages>10</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Aged Aged, 80 and over Complications Eye Eye (anatomy) Eye surgery Female Glaucoma Glaucoma, Open-Angle - surgery Humans Intraocular Pressure Low Tension Glaucoma - surgery Male Medicine Medicine & Public Health Ophthalmology Original Paper Phacoemulsification Retrospective Studies Stents Subgroups Surgery Surgical outcomes Trabecular Meshwork - surgery |
| title | 12-Month Outcomes of Combined Phacoemulsification and iStent Inject in Asian Eyes with Normal Tension Glaucoma: A Single-Centre Experience |
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