The effect of late-follicular phase progesterone elevation on embryo ploidy and cumulative live birth rates

•Progesterone elevation on the day of trigger does not have any detrimental effect on embryo euploidy rate.•Progesterone elevation does not affect the blastocyst formation rate or pregnancy outcomes following euploid FET.•This is the first study to evaluate the influence of progesterone elevation on...

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Published in:Reproductive biomedicine online 2021-12, Vol.43 (6), p.1063-1069
Main Authors: Neves, Ana Raquel, Santos-Ribeiro, Samuel, García-Martínez, Sandra, Devesa, Marta, Soares, Sérgio R., García-Velasco, Juan Antonio, Garrido, Nicolás, Polyzos, Nikolaos P.
Format: Article
Language:English
Subjects:
Adult
Birth Rate
Cross-Sectional Studies
Cumulative live birth rate
Elevated progesterone
Embryo quality
Embryo Transfer
Female
Follicular Phase - blood
Frozen embryo transfer
Humans
Live Birth
Ovulation Induction
PGT-A
Ploidies
Pregnancy
Pregnancy Rate
Progesterone - blood
Retrospective Studies
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Summary:•Progesterone elevation on the day of trigger does not have any detrimental effect on embryo euploidy rate.•Progesterone elevation does not affect the blastocyst formation rate or pregnancy outcomes following euploid FET.•This is the first study to evaluate the influence of progesterone elevation on both embryo ploidy and CLBR. Does late-follicular phase progesterone elevation have a deleterious effect on embryo euploidy, blastocyst formation rate and cumulative live birth rates (CLBR)? A multicentre retrospective cross-sectional study including infertile patients aged 18–40 years who underwent ovarian stimulation in a gonadotrophin-releasing hormone antagonist protocol and preimplantation genetic testing for aneuploidies (PGT-A) followed by a freeze-all strategy and euploid embryo transfer between August 2017 and December 2019. The sample was stratified according to the progesterone concentrations on the day of trigger: normal (≤1.50 ng/ml) and high (>1.50 ng/ml). Moreover, sensitivity analyses were performed to determine whether different conclusions would have been drawn if different cut-offs had been adopted. The primary outcome was the embryo euploidy rate. Secondary outcomes were the blastocyst formation rate, the number of euploid blastocysts and CLBR. Overall 1495 intracytoplasmic sperm injection PGT-A cycles were analysed. Late-follicular phase progesterone elevation was associated with significantly higher late-follicular oestradiol concentrations (2847.56 ± 1091.10 versus 2240.94 ± 996.37 pg/ml, P 
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2021.07.019