Recent advances in continuous flow synthesis of heterocycles

In the current scenario, flow chemistry is emerging as a significant technology in the field of organic synthesis. This miniaturized protocol including microreactors facilitates excellent heat transfer, low solvent wastage, lesser reaction time, a safer environment for reagent handling and appreciab...

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Bibliographic Details
Published in:Molecular diversity 2022-10, Vol.26 (5), p.2939-2948
Main Authors: Goel, Shruti, Khulbe, Mihir, Aggarwal, Anshul, Kathuria, Abha
Format: Article
Language:English
Subjects:
Batch processes
Biochemistry
Biomedical and Life Sciences
Chemical synthesis
Chemistry
Chemists
Heat transfer
Life Sciences
Organic chemicals
Organic Chemistry
Pharmacy
Polymer Sciences
Reactors
Reagents
Short Review
Solvents
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Summary:In the current scenario, flow chemistry is emerging as a significant technology in the field of organic synthesis. This miniaturized protocol including microreactors facilitates excellent heat transfer, low solvent wastage, lesser reaction time, a safer environment for reagent handling and appreciable yields of desired products. Thus, this “enabling technology” has a great scope in the synthesis and preparation of a variety of heterocycles that require toxic reagents as starting materials. This review discusses the recent advances (2020–2021) in continuous flow strategy for synthesis and derivatization of variety of heterocyclic entities, of different ring size, using different approaches. This also highlights the advantages of different combined techniques like Microwave assisted heating, electrochemical flow cell, LED light source, NMR and FT-IR analysis, etc., that enables utilization of various mechanisms and real-time monitoring of reactions leading to improved results. Graphic abstract
ISSN:1381-1991
1573-501X
DOI:10.1007/s11030-021-10338-9