Assessment of vaginal and endometrial microbiota by real‐time PCR in women with unexplained infertility

Aim Microbiota of the reproductive tract may be associated with unexplained infertility in women. We aimed to determine the derangements of vaginal and endometrial microbiota related to unexplained infertility by real‐time polymerase chain reaction (real‐time PCR) microbiota analyses of vaginal and...

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Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2022-01, Vol.48 (1), p.129-139
Main Authors: Sezer, Ozlem, Soyer Çalışkan, Canan, Celik, Samettin, Kilic, Suleyman Sirri, Kuruoglu, Tuba, Unluguzel Ustun, Goksenin, Yurtcu, Nazan
Format: Article
Language:English
Subjects:
Endometrium
Faith
Female
Flora
Humans
Infertility
Lactobacillus
Menstrual cycle
Microbiota
Polymerase chain reaction
Real-Time Polymerase Chain Reaction
real‐time PCR
Reproductive system
unexplained infertility
Vagina
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Summary:Aim Microbiota of the reproductive tract may be associated with unexplained infertility in women. We aimed to determine the derangements of vaginal and endometrial microbiota related to unexplained infertility by real‐time polymerase chain reaction (real‐time PCR) microbiota analyses of vaginal and endometrial samples of the unexplained infertility patients and fertile women. Materials and Methods Twenty‐six women with unexplained infertility and 26 age‐matched fertile women were included. Vaginal and endometrial samples were obtained in the mid‐menstrual cycle for analysis by quantitative real‐time PCR method. Results The proportion of lactobacilli‐impaired microbiota was significantly higher in the vaginal samples of unexplained infertility patients (76.9% vs. 26.9%; p 
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.15060