Serological response to mRNA and inactivated COVID-19 vaccine in healthcare workers in Hong Kong: decline in antibodies 12 weeks after two doses

• Published in: Hong Kong medical journal = Xianggang yi xue za zhi 2021-10, Vol.27 (5), p.380-383
• Main Authors: Zee, J S T, Lai, K T W, Ho, M K S, Leung, A C P, Fung, L H, Luk, W P, Kwok, L F, Kee, K M, Chan, Q W L, Tang, S F, Ma, E S K, Lee, K H, Lau, C C, Yung, R W H
• Format: Article
• Language: English
• Subjects: Adult; Antibodies; Antibodies, Neutralizing - blood; BNT162 Vaccine; Coronaviruses; COVID-19 - epidemiology; COVID-19 - prevention & control; COVID-19 vaccines; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Ethics; Female; Health Personnel - statistics & numerical data; Hong Kong - epidemiology; Humans; Immunogenicity, Vaccine; Immunoglobulin G - blood; Immunoglobulins; Logistic Models; Male; Medical personnel; Middle Aged; mRNA Vaccines; SARS-CoV-2; Serologic Tests - methods; Serologic Tests - statistics & numerical data; Serology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - immunology; Vaccines, Inactivated - administration & dosage; Vaccines, Inactivated - immunology; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology
• ISSN: 1024-2708; 2226-8707
• DOI: 10.12809/hkmj219744

To the Editor—We previously reported serological findings of 302 healthcare workers (HCWs) who completed two doses of mRNA (BNT162b2/Comirnaty; Fosun-BioNTech Pharma) and inactivated COVID-19 vaccine (CoronaVac; Sinovac Life Sciences, Beijing, China).1 Both vaccines were found to be immunogenic in the majority of HCWs. Ethics approval This study obtained ethics approval (Ref RC-2021-07) from the Research Ethics Committee of the Hong Kong Sanatorium [and] Hospital Medical Group. 1. Jonpaul ST Zee 1,2; Kristi TW Laisc 1; Matthew KS Ho 1; Alex CP Leung 1; LH Fung 3; WP Luk 3; LF Kwok 4; KM Kee 4; Queenie WL Chan 2; SF Tang 1,2; Edmond SK Ma 1; KH Lee 5; CC Lau 5; Raymond WH Yung 1,2,5 1 Department of Pathology, Hong Kong Sanatorium & Hospital, Hong Kong 2 Infection Control Team, Hong Kong Sanatorium & Hospital, Hong Kong 3 Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Hong Kong 4 Quality and Safety Division, Hong Kong Sanatorium & Hospital, Hong Kong 5 Hospital Administration, Hong Kong Sanatorium & Hospital, Hong Kong