Mechanical stimuli-mediated modulation of bone cell function—implications for bone remodeling and angiogenesis

Bone remodeling, expressed as bone formation and turnover, is a complex and dynamic process closely related to its form and function. Different events, such as development, aging, and function, play a critical role in bone remodeling and metabolism. The ability of the bone to adapt to new loads and...

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Bibliographic Details
Published in:Cell and tissue research 2021-12, Vol.386 (3), p.445-454
Main Authors: Liang, Wenqing, Wu, Xudong, Dong, Yongqiang, Chen, Xuerong, Zhou, Ping, Xu, Fangming
Format: Article
Language:English
Subjects:
Aging
Angiogenesis
Animals
Biomedical and Life Sciences
Biomedicine
Bone and Bones - metabolism
Bone growth
Bone remodeling
Bone Remodeling - genetics
Bone turnover
Cells
Human Genetics
Humans
Mechanical stimuli
Metabolism
Molecular Medicine
Osteogenesis
Osteoporosis - physiopathology
Physiological aspects
Proteomics
Review
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Summary:Bone remodeling, expressed as bone formation and turnover, is a complex and dynamic process closely related to its form and function. Different events, such as development, aging, and function, play a critical role in bone remodeling and metabolism. The ability of the bone to adapt to new loads and forces has been well known and has proven useful in orthopedics and insightful for research in bone and cell biology. Mechanical stimulation is one of the most important drivers of bone metabolism. Interestingly, different types of forces will have specific consequences in bone remodeling, and their beneficial effects can be traced using different biomarkers. In this narrative review, we summarize the major mediators and events in bone remodeling, focusing on the effects of mechanical stimulation on bone metabolism, cell populations, and ultimately, bone health.
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-021-03532-6