Mechanical stimuli-mediated modulation of bone cell function—implications for bone remodeling and angiogenesis

Bone remodeling, expressed as bone formation and turnover, is a complex and dynamic process closely related to its form and function. Different events, such as development, aging, and function, play a critical role in bone remodeling and metabolism. The ability of the bone to adapt to new loads and...

Full description

Saved in:
Bibliographic Details
Published in:Cell and tissue research 2021-12, Vol.386 (3), p.445-454
Main Authors: Liang, Wenqing, Wu, Xudong, Dong, Yongqiang, Chen, Xuerong, Zhou, Ping, Xu, Fangming
Format: Article
Language:English
Subjects:
Aging
Angiogenesis
Animals
Biomedical and Life Sciences
Biomedicine
Bone and Bones - metabolism
Bone growth
Bone remodeling
Bone Remodeling - genetics
Bone turnover
Cells
Human Genetics
Humans
Mechanical stimuli
Metabolism
Molecular Medicine
Osteogenesis
Osteoporosis - physiopathology
Physiological aspects
Proteomics
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c473t-40b943a58f4c539caabbbb64d06427b12b8241c4bc083993f061292494ca404f3
cites cdi_FETCH-LOGICAL-c473t-40b943a58f4c539caabbbb64d06427b12b8241c4bc083993f061292494ca404f3
container_end_page 454
container_issue 3
container_start_page 445
container_title Cell and tissue research
container_volume 386
creator Liang, Wenqing
Wu, Xudong
Dong, Yongqiang
Chen, Xuerong
Zhou, Ping
Xu, Fangming
description Bone remodeling, expressed as bone formation and turnover, is a complex and dynamic process closely related to its form and function. Different events, such as development, aging, and function, play a critical role in bone remodeling and metabolism. The ability of the bone to adapt to new loads and forces has been well known and has proven useful in orthopedics and insightful for research in bone and cell biology. Mechanical stimulation is one of the most important drivers of bone metabolism. Interestingly, different types of forces will have specific consequences in bone remodeling, and their beneficial effects can be traced using different biomarkers. In this narrative review, we summarize the major mediators and events in bone remodeling, focusing on the effects of mechanical stimulation on bone metabolism, cell populations, and ultimately, bone health.
doi_str_mv 10.1007/s00441-021-03532-6
format article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2583442776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A682856172</galeid><sourcerecordid>A682856172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c473t-40b943a58f4c539caabbbb64d06427b12b8241c4bc083993f061292494ca404f3</originalsourceid><addsrcrecordid>eNp9ks2K1TAUx4MozvXqC7iQgiBuOuarabMcBr9gxI2Cu5CmSW-GNLkm7WJ2PoRP6JN4Oh1HR8SEkK_f_5Bz8kfoKcGnBOP2VcGYc1JjCoM1jNbiHtoRDgvctd19tMMM07oV4ssJelTKJcaECyEfohMGMwjIDh0_WHPQ0RsdqjL7aQm-nuzg9WyHakrDEvTsU6ySq_oUbWVsCJVbollPf3z77qdjAPG6K5VLeaOyBakNPo6VjgOM0afRRlt8eYweOB2KfXIz79HnN68_nb-rLz6-fX9-dlEb3rK55riXnOmmc9w0TBqte2iCD1hw2vaE9h3lxPDe4I5JyRwWhErKJTeaY-7YHr3c4h5z-rrYMqvJl_X1Otq0FEWbjnEI1QpAn_-FXqYlR3gdULKVrKVQ3ltq1MEqH12aszZrUHUmOto1ggC3R6f_oKAPdvIGauM8nN8RvPhDcLA6zIeSwnJd0bsg3UCTUynZOnXMftL5ShGsVj-ozQ8K_KCu_aDW1J7dpLb08K23kl8GAIBtQIGrONr8O_f_hP0J_ga_gQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2597937235</pqid></control><display><type>article</type><title>Mechanical stimuli-mediated modulation of bone cell function—implications for bone remodeling and angiogenesis</title><source>Springer Link</source><creator>Liang, Wenqing ; Wu, Xudong ; Dong, Yongqiang ; Chen, Xuerong ; Zhou, Ping ; Xu, Fangming</creator><creatorcontrib>Liang, Wenqing ; Wu, Xudong ; Dong, Yongqiang ; Chen, Xuerong ; Zhou, Ping ; Xu, Fangming</creatorcontrib><description>Bone remodeling, expressed as bone formation and turnover, is a complex and dynamic process closely related to its form and function. Different events, such as development, aging, and function, play a critical role in bone remodeling and metabolism. The ability of the bone to adapt to new loads and forces has been well known and has proven useful in orthopedics and insightful for research in bone and cell biology. Mechanical stimulation is one of the most important drivers of bone metabolism. Interestingly, different types of forces will have specific consequences in bone remodeling, and their beneficial effects can be traced using different biomarkers. In this narrative review, we summarize the major mediators and events in bone remodeling, focusing on the effects of mechanical stimulation on bone metabolism, cell populations, and ultimately, bone health.</description><identifier>ISSN: 0302-766X</identifier><identifier>EISSN: 1432-0878</identifier><identifier>DOI: 10.1007/s00441-021-03532-6</identifier><identifier>PMID: 34665321</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Aging ; Angiogenesis ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Bone and Bones - metabolism ; Bone growth ; Bone remodeling ; Bone Remodeling - genetics ; Bone turnover ; Cells ; Human Genetics ; Humans ; Mechanical stimuli ; Metabolism ; Molecular Medicine ; Osteogenesis ; Osteoporosis - physiopathology ; Physiological aspects ; Proteomics ; Review</subject><ispartof>Cell and tissue research, 2021-12, Vol.386 (3), p.445-454</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-40b943a58f4c539caabbbb64d06427b12b8241c4bc083993f061292494ca404f3</citedby><cites>FETCH-LOGICAL-c473t-40b943a58f4c539caabbbb64d06427b12b8241c4bc083993f061292494ca404f3</cites><orcidid>0000-0001-9770-882X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34665321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Wenqing</creatorcontrib><creatorcontrib>Wu, Xudong</creatorcontrib><creatorcontrib>Dong, Yongqiang</creatorcontrib><creatorcontrib>Chen, Xuerong</creatorcontrib><creatorcontrib>Zhou, Ping</creatorcontrib><creatorcontrib>Xu, Fangming</creatorcontrib><title>Mechanical stimuli-mediated modulation of bone cell function—implications for bone remodeling and angiogenesis</title><title>Cell and tissue research</title><addtitle>Cell Tissue Res</addtitle><addtitle>Cell Tissue Res</addtitle><description>Bone remodeling, expressed as bone formation and turnover, is a complex and dynamic process closely related to its form and function. Different events, such as development, aging, and function, play a critical role in bone remodeling and metabolism. The ability of the bone to adapt to new loads and forces has been well known and has proven useful in orthopedics and insightful for research in bone and cell biology. Mechanical stimulation is one of the most important drivers of bone metabolism. Interestingly, different types of forces will have specific consequences in bone remodeling, and their beneficial effects can be traced using different biomarkers. In this narrative review, we summarize the major mediators and events in bone remodeling, focusing on the effects of mechanical stimulation on bone metabolism, cell populations, and ultimately, bone health.</description><subject>Aging</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bone and Bones - metabolism</subject><subject>Bone growth</subject><subject>Bone remodeling</subject><subject>Bone Remodeling - genetics</subject><subject>Bone turnover</subject><subject>Cells</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Mechanical stimuli</subject><subject>Metabolism</subject><subject>Molecular Medicine</subject><subject>Osteogenesis</subject><subject>Osteoporosis - physiopathology</subject><subject>Physiological aspects</subject><subject>Proteomics</subject><subject>Review</subject><issn>0302-766X</issn><issn>1432-0878</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9ks2K1TAUx4MozvXqC7iQgiBuOuarabMcBr9gxI2Cu5CmSW-GNLkm7WJ2PoRP6JN4Oh1HR8SEkK_f_5Bz8kfoKcGnBOP2VcGYc1JjCoM1jNbiHtoRDgvctd19tMMM07oV4ssJelTKJcaECyEfohMGMwjIDh0_WHPQ0RsdqjL7aQm-nuzg9WyHakrDEvTsU6ySq_oUbWVsCJVbollPf3z77qdjAPG6K5VLeaOyBakNPo6VjgOM0afRRlt8eYweOB2KfXIz79HnN68_nb-rLz6-fX9-dlEb3rK55riXnOmmc9w0TBqte2iCD1hw2vaE9h3lxPDe4I5JyRwWhErKJTeaY-7YHr3c4h5z-rrYMqvJl_X1Otq0FEWbjnEI1QpAn_-FXqYlR3gdULKVrKVQ3ltq1MEqH12aszZrUHUmOto1ggC3R6f_oKAPdvIGauM8nN8RvPhDcLA6zIeSwnJd0bsg3UCTUynZOnXMftL5ShGsVj-ozQ8K_KCu_aDW1J7dpLb08K23kl8GAIBtQIGrONr8O_f_hP0J_ga_gQ</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Liang, Wenqing</creator><creator>Wu, Xudong</creator><creator>Dong, Yongqiang</creator><creator>Chen, Xuerong</creator><creator>Zhou, Ping</creator><creator>Xu, Fangming</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7SS</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9770-882X</orcidid></search><sort><creationdate>20211201</creationdate><title>Mechanical stimuli-mediated modulation of bone cell function—implications for bone remodeling and angiogenesis</title><author>Liang, Wenqing ; Wu, Xudong ; Dong, Yongqiang ; Chen, Xuerong ; Zhou, Ping ; Xu, Fangming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-40b943a58f4c539caabbbb64d06427b12b8241c4bc083993f061292494ca404f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aging</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bone and Bones - metabolism</topic><topic>Bone growth</topic><topic>Bone remodeling</topic><topic>Bone Remodeling - genetics</topic><topic>Bone turnover</topic><topic>Cells</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Mechanical stimuli</topic><topic>Metabolism</topic><topic>Molecular Medicine</topic><topic>Osteogenesis</topic><topic>Osteoporosis - physiopathology</topic><topic>Physiological aspects</topic><topic>Proteomics</topic><topic>Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Wenqing</creatorcontrib><creatorcontrib>Wu, Xudong</creatorcontrib><creatorcontrib>Dong, Yongqiang</creatorcontrib><creatorcontrib>Chen, Xuerong</creatorcontrib><creatorcontrib>Zhou, Ping</creatorcontrib><creatorcontrib>Xu, Fangming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Health &amp; Medical Collection (ProQuest Medical &amp; Health Databases)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell and tissue research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Wenqing</au><au>Wu, Xudong</au><au>Dong, Yongqiang</au><au>Chen, Xuerong</au><au>Zhou, Ping</au><au>Xu, Fangming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical stimuli-mediated modulation of bone cell function—implications for bone remodeling and angiogenesis</atitle><jtitle>Cell and tissue research</jtitle><stitle>Cell Tissue Res</stitle><addtitle>Cell Tissue Res</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>386</volume><issue>3</issue><spage>445</spage><epage>454</epage><pages>445-454</pages><issn>0302-766X</issn><eissn>1432-0878</eissn><abstract>Bone remodeling, expressed as bone formation and turnover, is a complex and dynamic process closely related to its form and function. Different events, such as development, aging, and function, play a critical role in bone remodeling and metabolism. The ability of the bone to adapt to new loads and forces has been well known and has proven useful in orthopedics and insightful for research in bone and cell biology. Mechanical stimulation is one of the most important drivers of bone metabolism. Interestingly, different types of forces will have specific consequences in bone remodeling, and their beneficial effects can be traced using different biomarkers. In this narrative review, we summarize the major mediators and events in bone remodeling, focusing on the effects of mechanical stimulation on bone metabolism, cell populations, and ultimately, bone health.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34665321</pmid><doi>10.1007/s00441-021-03532-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9770-882X</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0302-766X
ispartof Cell and tissue research, 2021-12, Vol.386 (3), p.445-454
issn 0302-766X
1432-0878
language eng
recordid cdi_proquest_miscellaneous_2583442776
source Springer Link
subjects Aging
Angiogenesis
Animals
Biomedical and Life Sciences
Biomedicine
Bone and Bones - metabolism
Bone growth
Bone remodeling
Bone Remodeling - genetics
Bone turnover
Cells
Human Genetics
Humans
Mechanical stimuli
Metabolism
Molecular Medicine
Osteogenesis
Osteoporosis - physiopathology
Physiological aspects
Proteomics
Review
title Mechanical stimuli-mediated modulation of bone cell function—implications for bone remodeling and angiogenesis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T10%3A28%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mechanical%20stimuli-mediated%20modulation%20of%20bone%20cell%20function%E2%80%94implications%20for%20bone%20remodeling%20and%20angiogenesis&rft.jtitle=Cell%20and%20tissue%20research&rft.au=Liang,%20Wenqing&rft.date=2021-12-01&rft.volume=386&rft.issue=3&rft.spage=445&rft.epage=454&rft.pages=445-454&rft.issn=0302-766X&rft.eissn=1432-0878&rft_id=info:doi/10.1007/s00441-021-03532-6&rft_dat=%3Cgale_proqu%3EA682856172%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c473t-40b943a58f4c539caabbbb64d06427b12b8241c4bc083993f061292494ca404f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2597937235&rft_id=info:pmid/34665321&rft_galeid=A682856172&rfr_iscdi=true