It's time to deconstruct treatment-failure: A randomized controlled trial of nonoperative management of uncomplicated pediatric appendicitis with antibiotics alone

Published data demonstrate that management of uncomplicated pediatric appendicitis with antibiotics-alone is safe and frequently successful. Randomized controlled trials (RCT) comparing antibiotics-alone to appendectomy are lacking, alongside insight into drivers of failure. We sought to validate th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pediatric surgery 2022-01, Vol.57 (1), p.56-62
Main Authors: Perez Otero, Sofia, Metzger, Julia W., Choi, Beatrix H., Ramaraj, Akila, Tashiro, Jun, Kuenzler, Keith A., Ginsburg, Howard B., Tomita, Sandra S., Fisher, Jason C.
Format: Article
Language:English
Subjects:
Acute Disease
Anti-Bacterial Agents - therapeutic use
Antibiotics
Appendectomy
Appendicitis
Appendicitis - drug therapy
Appendicitis - surgery
Child
Follow-Up Studies
Humans
Nonoperative management
Pediatric
Randomized controlled trial
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Published data demonstrate that management of uncomplicated pediatric appendicitis with antibiotics-alone is safe and frequently successful. Randomized controlled trials (RCT) comparing antibiotics-alone to appendectomy are lacking, alongside insight into drivers of failure. We sought to validate the antibiotics-alone approach and identify barriers to success using an RCT design. Patients aged 6–17 years with uncomplicated appendicitis were randomized to appendectomy or intravenous piperacillin/tazobactam for 24–48 h followed by 10 days of oral ciprofloxacin/metronidazole. Enrollment required symptoms
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2021.09.024