A One-Pot Synthesis of Glycans and Nucleosides Based on ortho-(1-Phenylvinyl)benzyl Glycosides

One-pot synthesis of both glycans and nucleosides remains rare and challenging. Herein, we report a one-pot glycosylation strategy for glycans and nucleosides synthesis based on ortho-(1-phenylvinyl)­benzyl glycosides, which has several advantages, including no aglycon transfers, no undesired interf...

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Bibliographic Details
Published in:Organic letters 2021-11, Vol.23 (21), p.8257-8261
Main Authors: Yang, Rui, He, Haiqing, Chen, Zixi, Huang, Yingying, Xiao, Guozhi
Format: Article
Language:English
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Summary:One-pot synthesis of both glycans and nucleosides remains rare and challenging. Herein, we report a one-pot glycosylation strategy for glycans and nucleosides synthesis based on ortho-(1-phenylvinyl)­benzyl glycosides, which has several advantages, including no aglycon transfers, no undesired interference of departing species, no unpleasant odor, and up to the construction of four different glycosidic linkages.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c02998