Efficacy of a calcium‐phosphate/fluoride varnish and ionomeric sealant on cervical dentin hypersensitivity: A randomized, double‐blind, placebo‐controlled clinical study

• Published in: Journal of oral rehabilitation 2022-01, Vol.49 (1), p.62-70
• Main Authors: Machado, Alana Cristina, Maximiano, Vinícius, Yoshida, Mirian Lumi, Freitas, Julia Gomes, Mendes, Fausto Medeiros, Aranha, Ana Cecilia Corrêa, Scaramucci, Taís
• Format: Article
• Language: English
• Subjects: Calcium; Calcium Fluoride; Calcium phosphates; clinical trial; Clinpro WV Varnish; Clinpro XT Varnish; Dentin; Dentin Desensitizing Agents; dentin hypersensitivity; Dentin Sensitivity - drug therapy; Double-Blind Method; Double-blind studies; Fluoride treatments; Fluorides; Fluorides, Topical; Humans; Hypersensitivity; in‐office treatments; Phosphates; Placebos; Quality of Life
• ISSN: 0305-182X; 1365-2842
• DOI: 10.1111/joor.13270

Background Dentin hypersensitivity (DH) is a common problem in the population that can have a significant impact on the quality of life of those who suffer from the condition. Objectives Compare the efficacy of two treatments for DH: Ca/PO4−/F− varnish (Clinpro White Varnish) and ionomeric sealant (IS) (Clinpro XT Varnish) with a placebo. Methods Participants (121) with at least one tooth with visual analogue scale (VAS) score of 4 and above were randomly and blindly allocated to the groups. Treatments were performed by a trained researcher. DH was evaluated by another blind researcher after the treatment and after 1 week, 4 weeks, 3 months and 6 months. After 4 weeks, placebo received the DH treatment with IS; thus, the participants were not assessed after 3 and 6 months. Primary outcome was DH reduction after 4 weeks. Differences in VAS scores in the other time intervals and entire values of VAS were considered secondary outcomes. Comparisons were made among the groups (α = 0.05). Results IS showed the highest VAS value difference between baseline and 4 weeks (mean ± SD: 3.7 ± 2.2), differing significantly from placebo (2.3 ± 1.7) and Ca/PO4/F− varnish (2.6 ± 2.0). Ca/PO4−/F− varnish did not differ from placebo. In all time intervals, VAS values of all groups were significantly lower than the baseline value, without differences among groups. For the long‐term differences in VAS values (3 and 6 months), the IS exhibited significantly higher values than Ca/PO4−/F− varnish. Conclusions The IS was the most efficacious product for reducing DH, whereas Ca/PO4−/F− varnish did not differ from placebo. Registered in ClinicalTrials.gov (NCT04591444). Comparation of a Calcium‐Phosphate/Fluoride Varnish and a Ionomeric Sealant for Cervical Dentin Hypersensitivity: a randomized, double‐‐blind, placebo‐controlled clinical study.