Long-term assessment of bilirubin and transaminase trends in pediatric intestinal failure patients during the era of hepatoprotective parenteral nutrition

This study aimed to characterize the relationship between hepatoprotective parenteral nutrition (PN) dependence and long-term serum liver tests in children with intestinal failure (IF). A retrospective review was performed of children with severe IF (> 90 consecutive days of PN) who were followed...

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Bibliographic Details
Published in:Journal of pediatric surgery 2022-01, Vol.57 (1), p.122-126
Main Authors: Keefe, Gregory, Culbreath, Katherine, Knell, Jamie, Chugh, Priyanka V., Staffa, Steven J., Jaksic, Tom, Modi, Biren P.
Format: Article
Language:English
Subjects:
Alanine Transaminase
Bilirubin
Child
Fat Emulsions, Intravenous
Fish Oils
Humans
Intestinal Diseases - therapy
Intestinal Failure
Intestinal failure associated liver disease (IFALD)
Parenteral Nutrition
Pediatric intestinal failure
Retrospective Studies
Short Bowel Syndromew
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Summary:This study aimed to characterize the relationship between hepatoprotective parenteral nutrition (PN) dependence and long-term serum liver tests in children with intestinal failure (IF). A retrospective review was performed of children with severe IF (> 90 consecutive days of PN) who were followed from 2012 to 2019 at a multidisciplinary intestinal rehabilitation program. Patients were stratified into three groups based on level of PN dependence at most recent follow up: EN (achieved enteral autonomy), mixed (parenteral and enteral nutrition), and PN (> 75% of caloric intake from PN). PN at any point for this cohort was hepatoprotective, defined as soy-based lipids
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2021.09.018