Additional Effect of Coronary High-Intensity Plaque on T1-Weighted Magnetic Resonance Imaging With Circulating Malondialdehyde-Modified Low-Density Lipoprotein on Cardiac Events

• Published in: Circulation Journal 2021/10/25, Vol.85(11), pp.2032-2039
• Main Authors: Hiraya, Daigo, Sato, Akira, Hoshi, Tomoya, Sakai, Shunsuke, Watabe, Hiroaki, Ieda, Masaki
• Format: Article
• Language: English
• Subjects: Cardiac events; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - therapy; Coronary high-intensity plaque; Humans; Lipoproteins, LDL; Magnetic Resonance Imaging; Malondialdehyde; Malondialdehyde-modified low-density lipoprotein; Percutaneous Coronary Intervention; Plaque, Atherosclerotic - diagnostic imaging; Plaque, Atherosclerotic - pathology
• ISSN: 1346-9843; 1347-4820; 1347-4820
• DOI: 10.1253/circj.CJ-21-0220

Background:Although elevated levels of oxidized low-density lipoprotein (LDL) could play a critical role in vulnerable plaque, there are no studies that have compared coronary high-intensity plaque (HIP) and circulating malondialdehyde-modified (MDA)-LDL levels for the prediction of cardiac events.Methods and Results:A total of 139 patients with coronary artery stenosis (>70%) were examined with non-contrast T1-weighted magnetic resonance imaging (MRI) (HIP: n=64, non-HIP: n=75). Scheduled percutaneous coronary intervention (PCI) for culprit lesions was performed within 48 h after MRI. HIP was defined as a signal intensity of coronary plaque to cardiac muscle ratio (PMR) ≥1.4. We evaluated the subsequent major adverse cardiac events (MACE) during the follow-up period (5.6±1.3 years). MDA-LDL levels were independently associated with the presence of HIP (P