Carotid arterial wall MRI of apolipoprotein e–deficient mouse at 7 T using DANTE-prepared variable-flip-angle rapid acquisition with relaxation enhancement

To optimize a sequence combining the delay alternating with nutation for tailored excitation (DANTE) preparative module with the variable-flip-angle rapid acquisition with relaxation enhancement (VF-RARE) sequence (DANTE-VF-RARE) and to investigate its feasibility for vessel wall imaging in Apolipop...

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Bibliographic Details
Published in:Magnetic resonance imaging 2022-02, Vol.86, p.1-9
Main Authors: Yang, Yuanbo, Li, Zhonghao, Liu, Qiang, Guo, Yihao, Mei, Yingjie, Lyu, Jian, Zhao, Ming, Feng, Yanqiu, Xie, Guoxi
Format: Article
Language:English
Subjects:
Animals
ApoE−/− mouse
Apolipoproteins E - metabolism
Atherosclerosis
Carotid arterial wall imaging
Carotid Arteries - diagnostic imaging
Carotid Arteries - metabolism
DANTE
Imaging, Three-Dimensional - methods
Magnetic Resonance Angiography - methods
Magnetic resonance imaging
Mice
Signal-To-Noise Ratio
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Summary:To optimize a sequence combining the delay alternating with nutation for tailored excitation (DANTE) preparative module with the variable-flip-angle rapid acquisition with relaxation enhancement (VF-RARE) sequence (DANTE-VF-RARE) and to investigate its feasibility for vessel wall imaging in Apolipoprotein E–Deficient (ApoE−/−) mouse at 7 Tesla (T). Specific T1/T2 values were used for producing a sharper vessel wall in the variable-flip-angle optimization scheme. The DANTE RF pulse flip angle and pulse train length were optimized for maximizing the wall-lumen contrast. ApoE−/− (fed high fat diet for 20/40/ 60 weeks, n = 9/4/4) and wild-type mice (controls, n = 3) were imaged at 7 T using VF-RARE, DANTE-VF-RARE, time-of-flight (TOF) angiography, and multi-slice T1-weighted 2D RARE coupled with inflow outflow saturation bands (IOSB-RARE). Wall-lumen contrast-to-noise-ratio efficiency (CNReff), lumen area (LA), and wall area (WA) were compared between DANTE-VF-RARE and 2D IOSB-RARE sequences. Additionally, linear regression analysis was conducted between MR measurements and histomorphometric planimetry results. Residual blood signal was observed in the four out of eighteen carotids on VF-RARE images, whereas it was significantly suppressed on DANTE-VF-RARE images. Compared with IOSB-RARE, DANTE-VF-RARE offered significantly improved CNReff (P 
ISSN:0730-725X
1873-5894
DOI:10.1016/j.mri.2021.10.026