Heterogeneity of Helicobacter pylori bab genotypes and their association with clinical outcomes in Korean gastroduodenal patients

In this study, we aimed to investigate the prevalence of bab genes (babA, babB, babC) at their three loci (loci A, B, and C) in Helicobacter pylori strains from varied clinical manifestations of Korean gastroduodenal patients. The overall prevalence of H. pylori Korean strains positive for babA and...

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Bibliographic Details
Published in:The New microbiologica 2021-07, Vol.44 (3), p.155-160
Main Authors: Boonyanugomol, Wongwarut, Rukseree, Kamolchanok, Baik, Seung-Chul, Jung, Myunghwan, Shin, Min-Kyoung, Kang, Hyung-Lyun, Lee, Woo-Kon
Format: Article
Language:English
Subjects:
Adhesins, Bacterial - genetics
Bacterial Outer Membrane Proteins - genetics
Clinical outcomes
Gastric cancer
Gastritis
Gastritis - genetics
Gastritis - microbiology
Genotype
Genotypes
Helicobacter pylori
Helicobacter pylori - genetics
Helicobacter pylori - isolation & purification
Heterogeneity
Humans
Loci
Patients
Peptic Ulcer - epidemiology
Peptic Ulcer - microbiology
Peptic ulcers
Republic of Korea
Stomach Neoplasms - microbiology
Strains (organisms)
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Summary:In this study, we aimed to investigate the prevalence of bab genes (babA, babB, babC) at their three loci (loci A, B, and C) in Helicobacter pylori strains from varied clinical manifestations of Korean gastroduodenal patients. The overall prevalence of H. pylori Korean strains positive for babA and babB was 91.1% and 92.2%, respectively, but all strains were negative for bab C. H. pylori strains with two loci occupied (loci A and B) were the most prevalent in Korean patients (85.6%), compared to one locus occupied (14.4%) (locus A or B). Twelve bab genotypes were detected, additionally, the distribution of three bab genotypes was significantly associated with different clinical outcomes among Korean patients. The genotypes babA/babB/- and babA/babA+babB/- were significantly associated with peptic ulcer disease (PUD) (63.3%) and gastritis (GT) (33.3%) patients, respectively. In addition, we found that the babA+babB/babA+babB/- genotype was significantly associated with gastric cancer (GC) (36.7%) as compared to GT (6.7%) or PUD (6.7%) (p
ISSN:1121-7138