Role of formin INF2 in human diseases

Formin proteins catalyze actin nucleation and microfilament polymerization. Inverted formin 2 (INF2) is an atypical diaphanous-related formin characterized by polymerization and depolymerization of actin. Accumulating evidence showed that INF2 is associated with kidney disease focal segmental glomer...

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Bibliographic Details
Published in:Molecular biology reports 2022, Vol.49 (1), p.735-746
Main Authors: Zhao, Yiting, Zhang, Hui, Wang, Haibiao, Ye, Meng, Jin, Xiaofeng
Format: Article
Language:English
Subjects:
Actin
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Breast cancer
Depolymerization
Gastric cancer
Glioblastoma
Histology
Kidney diseases
Life Sciences
Molecular modelling
Morphology
Polymerization
Prostate cancer
Review
Thyroid cancer
Tumor suppressor genes
Tumors
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Summary:Formin proteins catalyze actin nucleation and microfilament polymerization. Inverted formin 2 (INF2) is an atypical diaphanous-related formin characterized by polymerization and depolymerization of actin. Accumulating evidence showed that INF2 is associated with kidney disease focal segmental glomerulosclerosis and cancers, such as colorectal and thyroid cancer where it functions as a tumor suppressor, glioblastoma, breast, prostate, and gastric cancer, via its oncogenic function. However, studies on the underlying molecular mechanisms of the different roles of INF2 in diverse cancers are limited. This review comprehensively describes the structure, biochemical features, and primary pathogenic mutations of INF2.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-021-06869-x