Evaluating the therapeutic effect and toxicity of theophylline in infertile men with asthenoteratozoospermia: a double-blind, randomized clinical trial study

Theophylline as a cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitor (cAMP-PDEI) elevates cAMP levels. We aimed to evaluate the therapeutic effect and toxicity of theophylline on the sperm parameters, oxidative stress (OS), and inflammation in asthenoteratozoospermic men. Sixty asthen...

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Published in:Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2022-11, Vol.45 (6), p.2786-2793
Main Authors: Azimi, Atena Sadat, Soleimani Mehranjani, Malek, Shariatzadeh, Seyed Mohammad Ali, Noshad Kamran, Alireza, Ghafarizadeh, Ali Asghar
Format: Article
Language:English
Subjects:
asthenoteratozoospermia
DNA fragmentation
inflammation
oxidative stress
Theophylline
toxicity
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Summary:Theophylline as a cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitor (cAMP-PDEI) elevates cAMP levels. We aimed to evaluate the therapeutic effect and toxicity of theophylline on the sperm parameters, oxidative stress (OS), and inflammation in asthenoteratozoospermic men. Sixty asthenoteratozoospermic patients were divided into groups of placebo and theophylline (200 mg/day). After 3 months of oral treatment, sperm parameters, viability, and DNA fragmentation were analyzed by the CASA system, eosin nigrosin staining, sperm DNA fragmentation kit, respectively. The seminal plasma level of reactive oxygen species (ROS) of neat semen samples, malondialdehyde (MDA), total antioxidant capacity (TAC), tumor necrosis factor alpha (TNF-α), and interleukin-10 (IL-10) was assessed. Data were analyzed statistically using the independent samples t-test and the paired t-test and the means were considered significantly different at p 
ISSN:0148-0545
1525-6014
DOI:10.1080/01480545.2021.1991755