Rat Blood Leukocytes after Intravenous Injection of Magnetoliposomes on the Basis of Nanomagnetite

• Published in: Bulletin of experimental biology and medicine 2021-10, Vol.171 (6), p.774-777
• Main Authors: Mil’to, I. V., Ivanova, V. V., Shevtsova, N. M., Serebryakova, O. N., Ivanov, A. A., Gereng, E. A., Takhauov, R. M., Sukhodolo, I. V.
• Format: Article
• Language: English
• Subjects: Animals; Animals, Outbred Strains; Biomedical and Life Sciences; Biomedicine; Biotechnologies; Blood; Cell Biology; Cell number; Eosinophils - cytology; Eosinophils - drug effects; Injection; Injections, Intravenous; Internal Medicine; Intravenous administration; Laboratory Medicine; Leukocyte Count; Leukocytes (eosinophilic); Leukocytes (neutrophilic); Liposomes - administration & dosage; Liposomes - pharmacokinetics; Lymphocytes; Lymphocytes - cytology; Lymphocytes - drug effects; Magnetite; Magnetite Nanoparticles - administration & dosage; Male; Monocytes; Monocytes - cytology; Monocytes - drug effects; Nanoparticles; Neutrophils; Neutrophils - cytology; Neutrophils - drug effects; Pathology; Rats; Rodents; Time Factors
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-021-05314-0

The structure of blood neutrophils, eosinophils, monocytes, and lymphocytes and differential white blood count in adult rats were studied over 120 days after a single intravenous injection of magnetoliposomes based on nanomagnetite. Magnetoliposomes had no effect on the structure of neutrophils, eosinophils, monocytes, and lymphocytes. At the same time, injection of a suspension of magnetoliposomes based on magnetite nanoparticles led to a decrease in lymphocyte count and an increase in the count of monocytes and band and segmented neutrophils in the blood. These changes were transient and the parameters returned to normal by day 40-60 after injection.