Short-Term Hypocalcemia Prophylaxis With Calcitriol Before Thyroidectomy

Total thyroidectomy is the most common surgical treatment of thyroid diseases, and postoperative hypocalcemia is its most common complication. Hypocalcemia prolongs the patient's hospital stay and impairs his or her quality of life. Although a low vitamin D level is a recognized risk factor, th...

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Bibliographic Details
Published in:Deutsches Ärzteblatt international 2021-11, Vol.118 (47), p.799
Main Authors: Sonnenberg, Stefanie, Scheunchen, Mandy, Smaxwil, Constantin Aurel, Weih, Heimo, Vorländer, Christian, Langer, Peter, Ostermann, Aaltje, Holzer, Katharina, Zielke, Andreas
Format: Article
Language:English
Subjects:
Calcitriol - therapeutic use
Calcium - therapeutic use
Female
Humans
Hypocalcemia - epidemiology
Hypocalcemia - prevention & control
Male
Postoperative Complications - epidemiology
Quality of Life
Thyroidectomy - adverse effects
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Summary:Total thyroidectomy is the most common surgical treatment of thyroid diseases, and postoperative hypocalcemia is its most common complication. Hypocalcemia prolongs the patient's hospital stay and impairs his or her quality of life. Although a low vitamin D level is a recognized risk factor, the utility of preoperative vitamin D administration to prevent postoperative hypocalcemia is unclear. In this trial, therefore, we studied the effect of giving vitamin D before total thyroidectomy. In a multicenter, randomized, minimally interventional trial (registration number: DRKS 00005615), patients about to undergo total thyroidectomy were randomized either to an intervention group that received 0.5 μg of calcitriol per os twice daily for three days up to the day immediately before surgery, or to a control group that did not (no placebo was given). The primary endpoint was the absence of hypocalcemia (serum calcium
ISSN:1866-0452
1866-0452
DOI:10.3238/arztebl.m2021.0351