Personalized and Programmable Microneedle Dressing for Promoting Wound Healing

Microneedle (MN) dressings, with the ability of transdermal drug delivery, have played an essential role in the field of wound healing. However, patients may still feel uncomfortable when sensitive unhealing wounds are pieced by strong needles. Here, inspired by the structure of mosquito mouthparts,...

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Bibliographic Details
Published in:Advanced healthcare materials 2022-01, Vol.11 (2), p.e2101659-n/a
Main Authors: Wang, Yuqiu, Lu, Huihui, Guo, Maoze, Chu, Jianlin, Gao, Bingbing, He, Bingfang
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Bandages
Crystals
Customization
Drug delivery
Engraving
Humans
Hydrogels
Image restoration
Isopropylacrylamide
Medical dressings
Mice
microneedles
Mold dressing
mosquito mouthpart structures
Mouthparts
Needles
Object recognition
personalized design
Photonic crystals
programmable needles
Silicone rubber
Silicones
Ultrafines
Wound Healing
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Summary:Microneedle (MN) dressings, with the ability of transdermal drug delivery, have played an essential role in the field of wound healing. However, patients may still feel uncomfortable when sensitive unhealing wounds are pieced by strong needles. Here, inspired by the structure of mosquito mouthparts, which possess a fixation part and a liquid‐transferring part, we present a novel MN wound dressing with superfine needle tips, personalized pattern design, programmable needle length, and multiple mechanical strengths for intelligent and painless drug delivery. By simply stretching the silicone rubber (Ecoflex) molds before engraving, superfine MNs can be formed in the restored molds. Meanwhile, by utilizing intelligent image recognition, precise treatment for irregular wounds is achieved. Notably, combined with temperature‐responsive N‐isopropylacrylamide (NIPAM) hydrogel and inverse opal (IO) photonic crystals (PCs), a controllable drug release system has been achieved on MN dressings. Moreover, the performance of the MN dressing in facilitating wound recovery has been demonstrated by full‐thickness skin wounds of a mouse model. These results indicate that novel personalized and programmable MN wound dressings are of considerable value in the field of wound management. Mosquito mouthpart structure‐inspired microneedle dressing with personalized patterns, programmable needle length, multiple mechanical strength, superfine needle tips, and intelligent drug release is fabricated by replicating stretched negative molds. The two different materials, silk fibroin (SF) and polyurethane (PU), endow the microneedle (MN) dressing with better fixed effect and painless drug release. The MN dressing also present an outstanding applicability of promoting wound healing.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.202101659