Clinical impact of bloodstream infection on acute cholecystitis indicated for emergency cholecystectomy

• Published in: Journal of hepato-biliary-pancreatic sciences 2022-03, Vol.29 (3), p.322-328
• Main Authors: Hanabata, Yusuke, Yamanaka, Kenya, Shinkura, Akina, Kurimoto, Makoto, Aoki, Hikaru, Harada, Kaichiro, Kayano, Masashi, Tashima, Misaki, Tamura, Jun
• Format: Article
• Language: English
• Subjects: acute cholecystitis; Aged; Bile; bloodstream infection; Body mass index; Cholecystectomy; Cholecystectomy, Laparoscopic; Cholecystitis, Acute - surgery; Confidence intervals; elderly; emergencies; Gallbladder diseases; Humans; Infections; Retrospective Studies; Sepsis
• ISSN: 1868-6974; 1868-6982
• DOI: 10.1002/jhbp.1069

Background The significance of blood culture for acute cholecystitis remains unclear. Methods A retrospective cohort study was conducted on patients who underwent emergency cholecystectomy at Hyogo Prefectural Amagasaki General Medical Center to examine the clinical impact of bloodstream infection (BSI), focusing on the association of BSI with bactibilia and severity grade based on the Tokyo guidelines 2018 (TG18). Results Among 177 patients included in the study, 32 had positive and 145 had negative BSI. Significant differences were observed between the positive and negative BSI in terms of age, body mass index (BMI), the American Society of Anesthesiologists physical status (ASA‐PS) and TG18 severity score. The odds ratios of BSI for patients aged ≥72 years, with a BMI of ≤21.8, an ASA‐PS of ≥3E, and grade III acute cholecystitis were 3.45, 3.23, 2.43 and 4.51, respectively. In the multivariate analysis, lower BMI and grade III were significantly associated with BSI with odds ratios of 2.53 (95% confidence interval: 1.07‐6.21, P = .037) and 3.03 (95% confidence interval: 1.02‐8.82, P = .041). Bacterial species that could not be isolated in the bile culture alone were identified in blood culture on 10 (38.5%) of 26 patients. Conclusions Bloodstream infection is associated with grade III acute cholecystitis. Blood culture enables the identification of bacteria that cannot be isolated in bile culture. Blood culture should be obtained for patients with grade III acute cholecystitis who undergo emergency cholecystectomy. Highlight Hanabata and colleagues demonstrated that grade III acute cholecystitis was associated with bloodstream infection in patients undergoing emergency cholecystectomy. Bacteria that could not be isolated in the gallbladder bile culture were identified in approximately 40% of blood cultures, indicating the need to obtain blood and bile cultures in grade III acute cholecystitis.