Oxytocin induces lordosis behavior in female rats through the prostaglandin E2/GnRH signaling system

Intracerebroventricular (icv) administration of oxytocin (OT) induces robust lordosis behavior (lordosis quotient and lordosis intensity) in estrogen-primed rats. The present study explored the hypothesis that the OT-Prostaglandin E2-GnRH pathway (a pathway produced in astrocytes) is involved in the...

Full description

Saved in:
Bibliographic Details
Published in:Hormones and behavior 2021-11, Vol.136, p.105081-105081, Article 105081
Main Authors: Domínguez-Ordoñez, Raymundo, Garcia-Juárez, Marcos, Tapia-Hernández, Sandra, Luna-Hernández, Ailyn, Galindo-Madrid, Miriam Eli, Tecamachaltzi-Silvarán, Miriam B., Hoffman, Kurt L., Pfaus, James G., González-Flores, Oscar
Format: Article
Language:English
Subjects:
Animals
Dinoprostone - pharmacology
Female
GnRH
Gonadotropin-Releasing Hormone - metabolism
Gonadotropin-Releasing Hormone - pharmacology
Lordosis
Lordosis - chemically induced
Oxytocin
Oxytocin - pharmacology
PGE2
Rats
Rats, Sprague-Dawley
Sexual Behavior, Animal
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Intracerebroventricular (icv) administration of oxytocin (OT) induces robust lordosis behavior (lordosis quotient and lordosis intensity) in estrogen-primed rats. The present study explored the hypothesis that the OT-Prostaglandin E2-GnRH pathway (a pathway produced in astrocytes) is involved in the facilitation of lordosis behavior by icv infusion of OT (2 μg). In Experiment 1, we tested the involvement of the OT receptor (OTR) by infusion of the OTR antagonist, atosiban (ATO). OT-induced lordosis was significantly reduced at both 30 and 120 min by prior infusion of ATO. In Experiment 2, we studied the effects of aspirin (COX2 inhibitor) and ONO-AE3-208 (ONO; EP4 prostaglandin receptor antagonist) on OT-induced lordosis. Infusions of both compounds diminished OT-induced lordosis at both 120 and 240 min. In Experiment 3, the involvement of the GnRH-1 receptor inhibitor antide on OT-induced lordosis was evaluated. Antide significantly inhibited OT-induced lordosis at all times tested. These data indicate that the OT/PGE2/GnRH pathway is involved in the expression of OT-induced lordosis behavior, an effect that may be occurring directly in hypothalamic astrocytes. •Lordosis behavior induced by oxytocin involves oxytocin receptor.•Lordosis behavior induced by oxytocin involves COX2-PGE2 pathway.•Lordosis behavior induced by oxytocin involves GnRH-1 receptor.•Lordosis behavior induced by oxytocin involves PGE2-GnRH pathway.
ISSN:0018-506X
1095-6867
DOI:10.1016/j.yhbeh.2021.105081