Tumor-infiltrating lymphocytes (TILs) in feline melanocytic tumors: A preliminary investigation

•Tumor infiltrating lymphocytes (TILs) associate with cellular pleomorphism and mitotic count.•TILs are inversely associated with the expression of Melan A and PNL2.•Both CD3+ and CD20+ lymphocytes increase in association with the mitotic count.•TILs may be associated with malignancy features in fel...

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Published in:Veterinary immunology and immunopathology 2021-12, Vol.242, p.110337-110337, Article 110337
Main Authors: Porcellato, Ilaria, Silvestri, Serenella, Sforna, Monica, Banelli, Agnese, Lo Giudice, Adriana, Mechelli, Luca, Brachelente, Chiara
Format: Article
Language:English
Subjects:
Animals
Antigens, Neoplasm
B-lymphocytes
Biomarkers, Tumor
Cat Diseases - immunology
Cats
Feline
Immunohistochemistry
Lymphocytes
Lymphocytes, Tumor-Infiltrating - immunology
MART-1 Antigen
Melanoma
Melanoma - immunology
Melanoma - veterinary
Retrospective Studies
Skin Neoplasms - immunology
Skin Neoplasms - veterinary
T-lymphocytes
Tumor-infiltrating
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Summary:•Tumor infiltrating lymphocytes (TILs) associate with cellular pleomorphism and mitotic count.•TILs are inversely associated with the expression of Melan A and PNL2.•Both CD3+ and CD20+ lymphocytes increase in association with the mitotic count.•TILs may be associated with malignancy features in feline melanocytic tumors. The presence and the role of tumor-infiltrating lymphocytes (TILs) in different types of tumors, but particularly in melanoma, has become more and more investigated during the last decade, both in human and veterinary medicine. Melanocytic tumors are quite rare in cats, with diffuse iris melanoma being the most commonly diagnosed in this species. The aim of this study was to characterize the lymphocytic infiltration in feline melanocytic tumors and to analyze their association with the histological features of malignancy recognized in these tumors, as well as with the expression of the most commonly used immunohistochemical markers. Thirty-eight feline melanocytic tumors were retrospectively selected; histological and immunohistochemical characterization of the tumors (histologic criteria of malignancy; S100, Melan A, and PNL2 expression) and of TILs (presence/absence, density, distribution, and grade; CD3, CD20 expression) were performed and associations between them tested. Results showed that TILs grade increased with cellular pleomorphism (P 
ISSN:0165-2427
1873-2534
DOI:10.1016/j.vetimm.2021.110337