Effect of Gender on Prognosis in Patients With Takotsubo Syndrome (from a Nationwide Perspective)

• Published in: The American journal of cardiology 2022-01, Vol.162, p.6-12
• Main Authors: Vincent, Louis T., Grant, Jelani, Ebner, Bertrand, Maning, Jennifer, Montana, Paul, Olorunfemi, Odunayo, Olarte, Neal I., de Marchena, Eduardo, Munagala, Mrudula, Colombo, Rosario
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Age Factors; Aged; Cardiac arrhythmia; Cardiovascular disease; Cardioversion; Chronic obstructive pulmonary disease; Complications; Confidence intervals; Coronary vessels; Databases, Factual; Ejection fraction; Female; Fibrillation; Gender; Heart failure; Hospital Mortality; Hospitalization; Hospitals; Humans; Hypothyroidism; Injury prevention; Kidney diseases; Kidneys; Lung diseases; Male; Medical prognosis; Men; Middle Aged; Morbidity; Mortality; Obstructive lung disease; Patients; Post-menopause; Prognosis; Respiratory failure; Retrospective Studies; Risk; Sex Factors; Survival Rate; Takotsubo Cardiomyopathy - complications; Takotsubo Cardiomyopathy - diagnosis; Takotsubo Cardiomyopathy - mortality; Thrombocytopenia; United States; Ventricle; Womens health
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2021.09.026

Takotsubo syndrome (TTS) largely affects postmenopausal women but has been shown to carry increased mortality risk in men. We sought to evaluate nationwide in-hospital outcomes between men and women admitted with TTS to better characterize these disparities. Using the National Inpatient Sample database from 2011 to 2018, we identified a total of 48,300 hospitalizations with the primary diagnosis of TTS. The primary end point was in-hospital all-cause mortality. Secondary end points included in-hospital complications, length of stay, and discharge disposition. Men with TTS accounted for 8.9% of hospitalizations, were younger in age (62.0 ± 15.1 vs 66.8 ± 12.1 years, p