Differential virulence of infectious hematopoietic necrosis virus (IHNV) isolated from salmonid fish in Gangwon Province, Korea

The present study investigated the virulence and expression of innate immunity genes in isolates of infectious hematopoietic necrosis virus (IHNV) in Gangwon province, South Korea, by challenging rainbow trout, Atlantic salmon, and coho salmon. Eight IHNV isolates were used to infect RTG-2 cells for...

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Published in:Fish & shellfish immunology 2021-12, Vol.119, p.490-498
Main Authors: Kim, So-Sun, Kim, Kwang-Il, Yoo, Hae-Kyun, Han, Yu-Seon, Jegal, Myeong-Eun, Byun, Soon-Gyu, Lim, Hyun-Jeong, Park, Jang-Su, Kim, Yung-Jin
Format: Article
Language:English
Subjects:
Animals
Cumulative mortality
Fish Diseases
IHNV
Immunity gene
Infectious hematopoietic necrosis virus
Oncorhynchus mykiss
Rhabdoviridae Infections - veterinary
Salmonid
Virulence
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Summary:The present study investigated the virulence and expression of innate immunity genes in isolates of infectious hematopoietic necrosis virus (IHNV) in Gangwon province, South Korea, by challenging rainbow trout, Atlantic salmon, and coho salmon. Eight IHNV isolates were used to infect RTG-2 cells for viral replication using plaque assays. Three isolates with the highest replication rates, the RtPc0314g and RtPc0314c isolates of the JRt-Shizuoka type and the RtPc0816g isolate of the JRt-Nagano type, were experimentally infected into the fish. In rainbow trout, both RtPc0314c and RtPc0314g isolates showed 100% cumulative mortality while the RtPc0816g isolate showed 60% cumulative mortality for 14 days. In contrast, all three isolates showed
ISSN:1050-4648
1095-9947
DOI:10.1016/j.fsi.2021.10.038