Coffea arabica extracts and their chemical constituents in a murine model of gouty arthritis: How they modulate pain and inflammation

Coffea arabica is commonly known for its cardiotonic and neurotonic activities, but in some places’ folk medicine, like in Arabia and Africa, C. arabica is used to treat headache, migraine, the flu, anemia, oedema, asthenia, asthma, inflammation and wounds. Aims of the study: The aims were to evalua...

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Published in:Journal of ethnopharmacology 2022-02, Vol.284, p.114778-114778, Article 114778
Main Authors: Matosinhos, Rafaela Cunha, Bezerra, Juliana Pantaleão, Barros, Camila Helena, Fernandes Pereira Ferreira Bernardes, Ana Catharina, Coelho, Grazielle Brandão, Carolina de Paula Michel Araújo, Marcela, Dian de Oliveira Aguiar Soares, Rodrigo, Sachs, Daniela, Saúde-Guimarães, Dênia Antunes
Format: Article
Language:English
Subjects:
Analgesics - chemistry
Analgesics - pharmacology
Animals
Arthritis
Coffea - chemistry
Coffea arabica
Cytokine
Gout
Gout - drug therapy
Inflammation
Inflammation - drug therapy
Male
Mice
Mice, Inbred C57BL
Pain
Pain - drug therapy
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - pharmacology
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Summary:Coffea arabica is commonly known for its cardiotonic and neurotonic activities, but in some places’ folk medicine, like in Arabia and Africa, C. arabica is used to treat headache, migraine, the flu, anemia, oedema, asthenia, asthma, inflammation and wounds. Aims of the study: The aims were to evaluate if the aqueous extracts of Coffea arabica, prepared from beans with different degrees of roasting, and their main chemical constituents could exert an in vivo anti-gouty effect. Coffea extracts were obtained from the beans of not roasted, light, medium and dark roasted coffee and from decaffeinated and traditional coffees and were prepared with water at 25°C and at 98°C. C57BL/6 mice were induced to gout by an injection of monosodium urate crystals and treated with coffee extracts at doses of 25, 75 and 225 mg/kg and their chemical constituents at a dose of 10 mg/kg. The antinociceptive and anti-inflammatory effects were evaluated. Treatments with Coffea extracts prepared with water at 98°C were more effective to exert antinociceptive and anti-inflammatory activities than the ones prepared with water at 25°C. Caffeic and chlorogenic acids reduced hypernociception in animals when compared with negative control group (7.79 and 5.69 vs 18.53; P 
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2021.114778