Does Alzheimer's disease stem in the gastrointestinal system?

Over the last decades, our knowledge of the key pathogenic mechanisms of Alzheimer's disease (AD) has dramatically improved. Regarding the limitation of current therapeutic strategies for the treatment of multifactorial diseases, such as AD, to be translated into the clinic, there is a growing...

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Bibliographic Details
Published in:Life sciences (1973) 2021-12, Vol.287, p.120088-120088, Article 120088
Main Authors: Khodabakhsh, Pariya, Bazrgar, Maryam, Dargahi, Leila, Mohagheghi, Fatemeh, Asgari Taei, Afsaneh, Parvardeh, Siavash, Ahmadiani, Abolhassan
Format: Article
Language:English
Subjects:
Alzheimer Disease - epidemiology
Alzheimer Disease - metabolism
Alzheimer's disease
Animals
Brain - metabolism
Brain-Gut Axis - physiology
Dementia
Gastrointestinal disease
Gastrointestinal Diseases - epidemiology
Gastrointestinal Diseases - metabolism
Gastrointestinal system
Gastrointestinal Tract - metabolism
Humans
Life span
Literature reviews
Liver disease
Liver diseases
Liver Diseases - epidemiology
Liver Diseases - metabolism
Microbiota
Nerve degeneration
Neurodegenerative diseases
Risk analysis
Risk Factors
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Summary:Over the last decades, our knowledge of the key pathogenic mechanisms of Alzheimer's disease (AD) has dramatically improved. Regarding the limitation of current therapeutic strategies for the treatment of multifactorial diseases, such as AD, to be translated into the clinic, there is a growing trend in research to identify risk factors associated with the onset and progression of AD. Here, we review the current literature with a focus on the relationship between gastrointestinal (GI)/liver diseases during the lifespan and the incidence of AD, and discuss the possible mechanisms underlying the link between the diseases. We also aim to review studies evaluating the possible link between the chronic use of the most common GI medications and the future risk of AD development. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2021.120088