Genome-wide meta-analysis revealed several genetic loci associated with serum uric acid levels in Korean population: an analysis of Korea Biobank data

The serum uric acid (SUA) level is an important determinant of gout, hypertension, metabolic syndrome, and cardiovascular disease. Although previous genome-wide studies have identified multiple genetic variants associated with SUA, most genetic analyses have focused on individuals with European ance...

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Bibliographic Details
Published in:Journal of human genetics 2022-04, Vol.67 (4), p.231-237
Main Authors: Park, Jin Sung, Kim, Yunkyung, Kang, Jihun
Format: Article
Language:English
Subjects:
Adult
Biobanks
Biological Specimen Banks
Cardiovascular disease
Cardiovascular diseases
Epidemiology
Gene loci
Genetic analysis
Genetic diversity
Genetic Loci
Genome-wide association studies
Genome-Wide Association Study - methods
Genomes
Gout
Homeostasis
Humans
Meta-analysis
Metabolic syndrome
Orexin receptors
Polymorphism, Single Nucleotide
Population studies
Uric Acid
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Summary:The serum uric acid (SUA) level is an important determinant of gout, hypertension, metabolic syndrome, and cardiovascular disease. Although previous genome-wide studies have identified multiple genetic variants associated with SUA, most genetic analyses have focused on individuals with European ancestry; thus, understanding of the genetic architecture of SUA is currently limited for Asian populations. We conducted a genome-wide meta-analysis based on Korea Biobank data consistent with three cohorts; namely, the Korean Genome and Epidemiology Study (KoGES) Ansan and Ansung, KoGES Health Examinee, and KoGES Cardiovascular Disease Association studies. In total, 60,585 participants aged ≥40 years were included in the analysis of the three cohorts. We used logistic regression analyses to perform genome-wide association study (GWAS) adjustments for confounding variables. Subsequently, a meta-analysis was conducted by combining the analyses of the three GWASs. We identified 8,105 variants at 22 genetic loci with a P value 
ISSN:1434-5161
1435-232X
DOI:10.1038/s10038-021-00991-1