Effect of infection with Aeromonas hydrophila on antioxidant capacity, inflammation response, and apoptosis proteins in Chinese mitten crab (Eriocheir sinensis)

• Published in: Comparative biochemistry and physiology. Toxicology & pharmacology 2022-02, Vol.252, p.109220-109220, Article 109220
• Main Authors: Zheng, Nan, Wang, Ning, Wang, Zhuo-yu, Abdallah, Ghonimy, Zhang, Bao-yuan, Wang, Sen, Yao, Qi, Chen, Yu-ke, Wang, Qiu-ju, Zhang, Dong-ming
• Format: Article
• Language: English
• Subjects: Aeromonas hydrophila; Aeromonas hydrophila - physiology; Animals; Antioxidant; Antioxidants - metabolism; Apoptosis; Apoptosis - physiology; Brachyura - microbiology; Eriocheir sinensis; Gene Expression Regulation - drug effects; Host-Pathogen Interactions; Inflammation - metabolism; Inflammation response
• ISSN: 1532-0456; 1878-1659
• DOI: 10.1016/j.cbpc.2021.109220

Aeromonas hydrophila (A. hydrophila) as a serious bacterial disease endangering aquaculture and the Chinese mitten crabs (Eriocheir sinensis) industry. The present study was conducted to investigate the effects of A. hydrophila on the antioxidant, inflammation, immunity and apoptosis of the E. sinensis. The E. sinensis (female: 150 crabs and male: 150 crabs; 67.11 ± 0.76 g) were randomly divided into the control group (Foot injection with 200 μl PBS) and infection group (Foot injection with 200 μl A. hydrophila of 106 cfu/mL). The hepatopancreas and serum was collected to detect the related indicators after injection 24 h. The results showed that A. hydrophila significantly reduced the malondialdehyde (MDA) level and gamma-glutamyl-cysteine synthetase (γ-GCS) activity in the hepatopancreas of male and female crabs (P