Sex-specific associations of exposure to metal mixtures with telomere length change: Results from an 8-year longitudinal study

Studies on the relationships between exposure to metal mixtures and telomere length (TL) are limited, particularly longitudinal studies. Few studies are available on the potential sex-specific associations between metal exposures and TL change. We examined blood metal concentrations and TL at baseli...

Full description

Saved in:
Bibliographic Details
Published in:The Science of the total environment 2022-03, Vol.811, p.151327-151327, Article 151327
Main Authors: He, Junxiu, Ge, Xiaoting, Cheng, Hong, Bao, Yu, Feng, Xiuming, Zan, Gaohui, Wang, Fei, Zou, Yunfeng, Yang, Xiaobo
Format: Article
Language:English
Subjects:
Bayes Theorem
Cadmium
Female
Humans
Interactions
Longitudinal Studies
Male
Metal mixtures
Metals - toxicity
Rubidium
Sex-specific
Telomere
Telomere length change
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Studies on the relationships between exposure to metal mixtures and telomere length (TL) are limited, particularly longitudinal studies. Few studies are available on the potential sex-specific associations between metal exposures and TL change. We examined blood metal concentrations and TL at baseline (August 2012) and follow-up (June 2020) among 316 participants in a ferro-manganese refinery. The least absolute shrinkage and selection operator (LASSO) followed by the generalized linear model (GLM) was applied to evaluate the associations between multiple-metal exposures and TL change (TL in 2012 minus TL in 2020). Bayesian kernel machine regression (BKMR) was applied to cope with metal mixtures and evaluate their joint effects on TL change. Among men, three statistical methods consistently showed rubidium was negatively associated with TL change (β [95% CI] = −2.755 [−5.119, −0.391] in the GLM) and dominated the negative overall effects of 10 metal mixtures (magnesium, manganese, iron, cobalt, copper, zinc, selenium, rubidium, cadmium, and lead) on TL change (posterior inclusion probabilities = 0.816). Among women, the GLM (β [95% CI] = 4.463 [0.943, 7.983]) and LASSO (β = 4.289) showed rubidium was positively associated with TL change. Interestingly, no significant association was observed between exposure to metal mixtures and TL change in overall participants (P > 0.05). Furthermore, stratified analysis showed significant relationships between rubidium and TL change in men (β = −2.744), women (β = 3.624), and current smokers (β = −3.266) (both P interaction
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2021.151327