Rational Development of Dual-Ratiometric Fluorescent Probes for Distinguishing between H2S and SO2 in Living Organisms

For better investigating the complicated relationships between H2S and SO2, simultaneously detecting and visualizing them with good selectivity is crucial. However, most sensing mechanisms for H2S and SO2 probes are based on the addition reactions with the double bonds, which have no selectivity. In...

Full description

Saved in:
Bibliographic Details
Published in:Analytical chemistry (Washington) 2021-11, Vol.93 (45), p.15209-15215
Main Authors: Han, Shaohui, Zhang, Hui, Wang, Jingpei, Yang, Lei, Lan, Minhuan, Wang, Benhua, Song, Xiangzhi
Format: Article
Language:English
Subjects:
Chemistry
Coumarin
Fluorescent indicators
Hydrogen sulfide
Probes
Selectivity
Sulfur dioxide
Zebrafish
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:For better investigating the complicated relationships between H2S and SO2, simultaneously detecting and visualizing them with good selectivity is crucial. However, most sensing mechanisms for H2S and SO2 probes are based on the addition reactions with the double bonds, which have no selectivity. In this work, by introducing an active triple bond into 4-dicyanovinyl-7-diethylamino-coumarin, we construct two unique sensors for not only distinguishing between H2S and SO2 but also sensing H2S and SO2 in a dual-ratiometric manner. Moreover, the modified sensor was successfully applied in living cells and zebrafish for discriminating H2S and SO2.
ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.1c03963